Results 81 to 90 of about 27,279 (252)
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
, 2012 P27(Kip1) (p27) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Recently, a new function of p27 as transcriptional regulator has been reported.
Perearnau Garcia, Anna +12 more
core +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
, 2007 The DNA damage checkpoint response delays cell cycle progression upon DNA damage and prevents genomic instability. Genetic analysis has identified sensor, mediator, signal transducer, and effector components of this global signal transduction pathway ...
Choi, J.-H. +2 more
core +1 more source
, 2014 Prenatal stress influences the development of the fetal brain and so contributes to the risk of the development of psychiatric disorders in later life.
Jos Prickaerts (122782) +13 more
core +2 more sources
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Functions and pathways of differential proteins. (Enrichment p-value<0.05).
, 2013 Protein names corresponded to gene symbols: S100A6:S100 calcium binding protein A6; DTYMK:deoxythymidylatekinase; PA2G4:proliferation-associated 2G4; STAG2:stromal antigen 2; PCNA:proliferating cell nuclear antigen; PRKRA: interferon-inducible double ...
Yong Han (111920) +7 more
core +1 more source
Clonal analysis of growth behaviors during "Drosophila" larval tracheal development [PDF]
, 2009 The discovery of the de novo formation of a tracheal structure, air sac primordium (ASP), in the second thoracic tracheal metamere (Tr2) during the 3rd instar larval stage (L3), challenged the assumption that the tracheal system established during ...
Lin, Li
core +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source