Results 191 to 200 of about 7,998 (203)

Characterization of ADAR1-mediated modulation of gene expression

Biochemical and Biophysical Research Communications, 2008
Conversion of adenosine into inosine in RNA molecules constitutes an important post-transcriptional mechanism for generating transcript diversity and is catalyzed by adenosine deaminases acting on RNA (ADARs). Intriguingly, we observed that the editing enzyme ADAR1 enhances reporter gene expression in a cellular, plasmid-based system.
Willemijn M, Gommans, Stefan, Maas
openaire   +2 more sources

ADAR1 and its implications in cancer development and treatment

Trends in Genetics, 2022
The family of adenosine deaminases acting on RNA (ADARs) regulates global gene expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded RNA (dsRNA) and through interacting with RNA and other proteins. ADARs play important roles in development and disease, including an increasing connection to cancer progression.
Allison R, Baker, Frank J, Slack
openaire   +2 more sources

Adar1 restricts line-1 retrotransposition

2017
Adenosine deaminases acting on RNA (ADARs) are enzymes that catalyze the hydrolytic deamination of Adenosine (A) to Inosine (I) (AàI) in double-stranded RNA (dsRNA) substrates. This process is called RNA editing. In literature there are many studies describing ADAR1 as regulator of the replication of different viruses, exerting either a proviral or ...
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Identification of ADAR1 p150 and p110 Associated Edit Sites

2023
Adenosine deaminase acting on RNA 1 (ADAR1) catalyzes adenosine-to-inosine editing on double-stranded RNA molecules and is involved in regulating cellular responses to endogenous and exogenous RNA. ADAR1 is the primary A-to-I editor of RNA in humans, and the majority of edit sites are found in a class of short interspersed nuclear elements called Alu ...
Tony, Sun, Brad R, Rosenberg, Hachung, Chung, Charles M, Rice   +3 more
openaire   +2 more sources

In search of critical dsRNA targets of ADAR1

Trends in Genetics
Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive.
Erez Y. Levanon, Roni Cohen-Fultheim, Eli Eisenberg   +2 more
openaire   +2 more sources

Loss of ADAR1 induces ferroptosis of breast cancer cells

Cellular Signalling
Adenosine deaminases acting on RNA 1(ADAR1), an RNA editing enzyme that converts adenosine to inosine by deamination in double-stranded RNAs, plays an important role in occurrence and progression of various types of cancer. Ferroptosis has emerged as a hot topic of cancer research in recent years.
Chuan, Yin, Meng-Meng, Zhang, Guo-Liang, Wang, Xiao-Yan, Deng, Zeng, Tu, Shan-Shan, Jiang, Zheng-Dan, Gao, Meng, Hao, Yong, Chen, Yi, Li, Sheng-Yong, Yang   +10 more
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Microglial specific ADAR1 mutation exhibits different innate immune activation from ADAR1 gene deletion in the brain 4044

The Journal of Immunology
Abstract Description   Microglial specific ADAR1 mutation exhibits different innate immune activation from ADAR1 gene deletion in the brain Xinfeng Guo, Chaowei Shang, Clayton Wiley, Richard A. Steinman, Timothy R.
Xinfeng Guo, Chaowei Shang, Clayton Wiley, Richard Steinman, Timmithy Billiar, Qingde Wang   +5 more
openaire   +1 more source

P1.14-04 Silencing ADAR1 Abrogates Mesothelioma Tumorigenicity

Journal of Thoracic Oncology, 2022
B. Jacobson, M. Patel, R. Kratzke
openaire   +1 more source

ADAR1 regulates Mda5-MAVS

Nature Immunology, 2015
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ADAR1 inhibits ZBP1 activation by endogenous Z-RNA

Nature Reviews Genetics, 2022
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