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Structural analysis of human ADAR2-RNA complexes by X-ray crystallography [PDF]

Adenosine deaminases acting on RNAs (ADARs) are a class of RNA editing enzymes found in metazoa that catalyze the hydrolytic deamination of adenosine to inosine in duplexed RNA. Inosine is a nucleotide that can base pair with cytidine, therefore, inosine is interpreted by cellular processes as guanosine. ADARs are functionally important in RNA recoding
Campbell, Kristen B, Cheng, Jeff, Mendoza, Herra G, Karki, Agya, Beal, Peter A, Fisher, Andrew J   +5 more
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Harnessing Human ADAR2 for Site-Directed RNA Editing

2018
The catalytic deamination of adenosine to inosine is an essential posttranscriptional RNA modification. Since Inosine is biochemically read as guanosine, site-specific A-to-I RNA editing results in substitution of single amino acids and can lead to changes in processing and regulation of transcripts.
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Getting to the core of ADAR2 activity in AML

Blood, 2023
Kathleen Steel, Catriona Jamieson
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Effect of mismatch on binding of ADAR2/GluR-2 pre-mRNA complex

Journal of Molecular Modeling, 2015
RNA editing plays an important role in realizing the full potential of a given genome. Different from RNA splicing, RNA editing fine-tunes the sequence of RNA by changing only one or two nucleotides. A-I editing [deamination of adenosine (A) to create inosine (I)] is best characterized in mammals and occurs in the regions of double-stranded RNA (dsRNA).
Junru, Yang, Jianing, Song, John Z H, Zhang, Changge, Ji   +3 more
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Adar2 restricts line1 retrotransposition

2019
Adenosine deaminases that act on RNA (ADARs) catalyse the hydrolytic deamination of Adenosine (A) to Inosine (I) within double-stranded RNA substrates. In mammals three ADAR enzymes are present: ADAR1, ADAR2 and ADAR3. ADAR1 and ADAR2 are expressed in many tissues and they are catalytically active; ADAR3 is expressed only in the brain and its catalytic
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Investigating the role of ADAR2 in osteoblast and adipocyte differentiation

2022
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ADAR (adenosine deaminase of acting on RNA, ADAR1, ADAR2, ADAR3)

2012
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ADAR (adenosine deaminase of acting on RNA, ADAR1, ADAR2, ADAR3)

2008
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