Results 191 to 200 of about 4,102 (209)
Some of the next articles are maybe not open access.
Harnessing Human ADAR2 for Site-Directed RNA Editing
2018The catalytic deamination of adenosine to inosine is an essential posttranscriptional RNA modification. Since Inosine is biochemically read as guanosine, site-specific A-to-I RNA editing results in substitution of single amino acids and can lead to changes in processing and regulation of transcripts.
openaire +1 more source
Getting to the core of ADAR2 activity in AML
Blood, 2023Kathleen Steel, Catriona Jamieson
openaire +2 more sources
Effect of mismatch on binding of ADAR2/GluR-2 pre-mRNA complex
Journal of Molecular Modeling, 2015RNA editing plays an important role in realizing the full potential of a given genome. Different from RNA splicing, RNA editing fine-tunes the sequence of RNA by changing only one or two nucleotides. A-I editing [deamination of adenosine (A) to create inosine (I)] is best characterized in mammals and occurs in the regions of double-stranded RNA (dsRNA).
Junru, Yang +3 more
openaire +2 more sources
Adar2 restricts line1 retrotransposition
2019Adenosine deaminases that act on RNA (ADARs) catalyse the hydrolytic deamination of Adenosine (A) to Inosine (I) within double-stranded RNA substrates. In mammals three ADAR enzymes are present: ADAR1, ADAR2 and ADAR3. ADAR1 and ADAR2 are expressed in many tissues and they are catalytically active; ADAR3 is expressed only in the brain and its catalytic
openaire +1 more source