Results 171 to 180 of about 6,398,385 (224)

[Analysis of ADAR gene variants in a Chinese pedigree affected with Dyschromatosis symmetrica hereditaria in conjunct with developmental delay].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
To explore the clinical characteristics and genetic etiology for a Chinese pedigree affected with Dyschromatosis symmetrica hereditaria (DSH) in conjunct with developmental delay.A child who had presented at the First Affiliated Hospital of Zhengzhou University on May 28 2021 for abnormal skin pigmentation of the extremities and growth retardation for ...
Yu Zhang, Zheng Chen, Jiandong Wang, Guangshuai Wei, Jiechao Niu, Yao Wang, Huaili Wang   +6 more
semanticscholar   +4 more sources

A novel splice site mutation in theADARgene leading to exon skipping and dyschromatosis symmetrica hereditaria in a Japanese patient

Clinical and Experimental Dermatology, 2016
Osamu Ansai, Yohya Shigehara, Akiko Ito, Riichiro Abe, Yutaka Shimomura   +4 more
semanticscholar   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

[Analysis of ADAR gene variant in a Chinese pedigree affected with dyschromatosis symmetrica hereditaria].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2022
To analyze the clinical features and genetic basis for a Chinese pedigree affected with hereditary dyschromatosis symmetrica hereditaria (DSH).Peripheral blood samples of the proband and his mother were collected and subjected to PCR and Sanger sequencing.The patient has conformed to the typical pattern of DSH and manifested with hyperpigmentation ...
Changyin, Wang, Siman, Xia, Zhengjun, Cui, Xinjian, Liu, Kun, Qian, Qian, Li, Xin, Zong   +6 more
openaire   +3 more sources

Involvement of PU.1 in mouse adar-1 gene transcription induced by high-dose esiRNA

International Journal of Biological Macromolecules, 2009
Adar-1 gene plays an important role in the negative regulation of RNA interference. We previously showed that increased adar-1 mRNA level was associated with the rebound of gene expression after RNAi suppression. In this study, we identified a PU.1 binding site upstream from transcription start point of adar-1 gene and is essential for the promoter ...
Tongde Wu, Yingchun Zhao, Zhaojing Hao, Hongfeng Zhao, Weirong Wang   +4 more
openalex   +4 more sources

esiRNA to eri-1 and adar-1 genes improving high doses of c-myc-directed esiRNA effect on mouse melanoma growth inhibition

Biochemical and Biophysical Research Communications, 2007
Knockdown of c-myc expression via RNAi is expected to be an efficient approach to suppress tumor growth. In our preliminary study, we intraperitoneally injected different doses of c-myc-directed esiRNA (esic-MYC, c-myc-directed Escherichia coli expressed and enzyme digested siRNA) into C57BL6/6J mice with bearing B16 melanoma to investigate the ...
Jie Hong, Yinchun Zhao, Zhengwu Li, Weida Huang   +3 more
openalex   +4 more sources

Insights into ADAR Gene Complement, Expression Patterns, and RNA editing landscape in Chlamys farreri

Fish & Shellfish Immunology
Adenosine Deaminases Acting on RNA (ADARs) are evolutionarily conserved enzymes known to convert adenosine to inosine in double-stranded RNAs and participate in host-virus interactions. Conducting a meta-analysis of available transcriptome data, we identified and characterised eight ADAR transcripts in Chlamys farreri, a farmed marine scallop ...
Enrico Bortoletto, Umberto Rosani, Akari Sakaguchi, Jeongwoong Yoon, Kazue Nagasawa, Paola Venier   +5 more
openalex   +3 more sources

The Promoter-Proximal KCS Element of thePKRKinase Gene Enhances Transcription Irrespective of Orientation and Position Relative to the ISRE Element and Is Functionally Distinct from the KCS-like Element of theADARDeaminase Promoter

Journal of Interferon & Cytokine Research, 2002
The RNA-dependent protein kinase PKR promoter is interferon (IFN) inducible and possesses a novel 15-base pair (bp) constitutive activator element, designated kinase conserved sequence (KCS), in addition to an IFN-stimulated response element (ISRE). Deletion of the KCS element or point mutations within the KCS element greatly reduce both basal and IFN ...
Simone Visosky Ward, Danielle Markle, Sonali Das, Charles E. Samuel   +3 more
openalex   +4 more sources

Comparative Activity of Adenosine Deaminase Acting on RNA (ADARs) Isoforms for Correction of Genetic Code in Gene Therapy

Current Gene Therapy, 2018
Introduction: Members of the adenosine deaminase acting on RNA (ADAR) family of enzymes consist of double-stranded RNA-binding domains (dsRBDs) and a deaminase domain (DD) that converts adenosine (A) into inosine (I), which acts as guanosine (G) during translation.
Md Thoufic Anam Azad, Umme Qulsum, Toshifumi Tsukahara   +2 more
openalex   +4 more sources

F11R RNA trinucleotide over-edited by ADAR in gastric and colorectal cancers: cross-cohort validation, gene expression regulation, and diagnostic significance

Biochemical and Biophysical Research Communications
The F11 receptor (F11R) gene encoding junctional adhesion molecule A has been associated with gastric cancer (GC) and colorectal cancer (CRC), in which its role and regulation remain to be further elucidated. Recently F11R was also identified as a potential target of adenosine-to-inosine (A-to-I) mediated by the adenosine deaminases acting on RNA ...
Chuanqing Bao, Jun-Jie Feng, Jing Cui, Tao Guo, Yu-Shan He, Zhi-Yuan Wei, Cheng-Jia Qian, Yunyun Jin, Jian‐Huan Chen   +8 more
openalex   +3 more sources

A functional polymorphism in ADAR1 gene affects HBsAg seroclearance both spontaneously and interferon induced

Liver International, 2013
AbstractBackground & AimsOur previous study found that rs4845384 in ADAR1 gene to be associated with HBeAg seroconversion. However, the effect of rs4845384 on HBsAg seroclearance is unknown. To assess the relationship between rs4845384 and HBsAg seroclearance.MethodsTwo independent case–control studies were conducted to test whether rs4845384 in ...
Xiaopan Wu, Weimei Shi, Jia Wu, Xilin Zhu, Kangmei Chen, Sujun Zheng, Zhuo Li, Zhongping Duan, Hui Li, Ying Liu   +9 more
openalex   +4 more sources