Results 1 to 10 of about 3,576 (130)

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins [PDF]

Biomolecules, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam P. Keegan, Mary A. O'Connell   +4 more
doaj   +4 more sources

Deciphering the mechanistic roles of ADARs in cancer pathogenesis, tumor immune evasion, and drug resistance [PDF]

Frontiers in Immunology
RNA is a fundamental biological macromolecule that undergoes several post-transcriptional modifications, including adenosine to inosine (A-to-I) editing by adenosine deaminases acting on RNA (ADARs).
Xiaoke Wang, Fei Yin, Yangfang He, Yue Qiao, Yan Yan, Jingru Ma   +5 more
doaj   +2 more sources

Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae) [PDF]

BMC Genetics, 2009
Background ADARs are RNA editing enzymes that target double stranded RNA and convert adenosine to inosine, which is read by translation machinery as if it were guanosine. Aside from their role in generating protein diversity in the central nervous system,
O'Connell Mary A, Wilfert Lena, Keegan Liam P, Carpenter Jennifer A, Jiggins Francis M   +4 more
doaj   +6 more sources

Identification of exceptionally potent adenosine deaminases RNA editors from high body temperature organisms. [PDF]

PLoS Genetics, 2023
The most abundant form of RNA editing in metazoa is the deamination of adenosines into inosines (A-to-I), catalyzed by ADAR enzymes. Inosines are read as guanosines by the translation machinery, and thus A-to-I may lead to protein recoding.
Adi Avram-Shperling, Eli Kopel, Itamar Twersky, Orshay Gabay, Amit Ben-David, Sarit Karako-Lampert, Joshua J C Rosenthal, Erez Y Levanon, Eli Eisenberg, Shay Ben-Aroya   +9 more
doaj   +2 more sources

Charting and probing the activity of ADARs in human development and cell-fate specification [PDF]

Nature Communications
Adenosine deaminases acting on RNA (ADARs) impact diverse cellular processes and pathological conditions, but their functions in early cell-fate specification remain less understood.
Amir Dailamy, Weiqi Lyu, Sami Nourreddine, Michael Tong, Joseph Rainaldi, Daniella McDonald, Rebecca Panwala, Alysson Muotri, Michael S. Breen, Kun Zhang, Prashant Mali   +10 more
doaj   +2 more sources

TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data [PDF]

Genome Biology
RNA editing by adenosine deaminases acting on RNA (ADARs) is an essential cellular process performed by three enzymes in mammals: ADAR1-p150, ADAR1-p110, and ADAR2, demonstrating different target specificity and selectivity.
Maike Herrmann, Yvonne Krebs, Francisco M. Acosta, Sebastian Parusel, Oliver Siering, Felix G. M. Andres, Biruhalem Taye, Csaba Miskey, Christian K. Pfaller   +8 more
doaj   +2 more sources

Nucleoside Analogs in ADAR Guide Strands Enable Editing at 5′-GA Sites [PDF]

Biomolecules
Adenosine Deaminases Acting on RNA (ADARs) are members of a family of RNA editing enzymes that catalyze the conversion of adenosine into inosine in double-stranded RNA (dsRNA).
Aashrita Manjunath, Jeff Cheng, Kristen B Campbell, Casey S. Jacobsen, Herra G. Mendoza, Leila Bierbaum, Victorio Jauregui-Matos, Erin E. Doherty, Andrew J. Fisher, Peter A. Beal   +9 more
doaj   +2 more sources

Dimerization of ADAR1 modulates site-specificity of RNA editing [PDF]

Nature Communications
Adenosine-to-inosine editing is catalyzed by adenosine deaminases acting on RNA (ADARs) in double-stranded RNA (dsRNA) regions. Although three ADARs exist in mammals, ADAR1 is responsible for the vast majority of the editing events and acts on thousands ...
Allegra Mboukou, Vinod Rajendra, Serafina Messmer, Therese C. Mandl, Marjorie Catala, Carine Tisné, Michael F. Jantsch, Pierre Barraud   +7 more
doaj   +2 more sources

A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules [PDF]

Frontiers in Bioengineering and Biotechnology, 2015
RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita, Dario eVeneziano, Alfredo eFerro   +2 more
doaj   +3 more sources

RNA editing enzymes: structure, biological functions and applications [PDF]

Cell & Bioscience
With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been identified. However, only a few of these modifications can lead to base pair changes, which are called RNA editing.
Dejiu Zhang, Lei Zhu, Yanyan Gao, Yin Wang, Peifeng Li   +4 more
doaj   +2 more sources