Results 11 to 20 of about 4,312 (239)
ADAR Family Proteins: A Structural Review [PDF]
Current Issues in Molecular BiologyThis review aims to highlight the structures of ADAR proteins that have been crucial in the discernment of their functions and are relevant to future therapeutic development.
Carolyn N. Ashley +2 more
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Mathematical Biosciences and Engineering, 2023 To date, few studies have investigated whether the RNA-editing enzymes adenosine deaminases acting on RNA (ADARs) influence RNA functioning in lung adenocarcinoma (LUAD).
Siqi Hu +3 more
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ADAR RNA editing below the backbone [PDF]
RNA, 2017 ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago. Since then, studies on ADARs in genetic model organisms, and evolutionary comparisons between them, continue to reveal a surprising range of pleiotropic biological effects of ADARs. This review focuses
Liam P. Keegan +3 more
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Heterochromatin: On the ADAR Radar? [PDF]
Current Biology, 2005 Vigilin proteins, the absence of which is known to cause abnormalities in heterochromatin, have been found to bind edited RNAs. Molecular complexes including vigilin comprise proteins involved with RNA editing and with DNA repair, making connections between these processes and RNA-based silencing mechanisms.
Harvey R. Fernandez +3 more
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ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications [PDF]
Annals of Translational Medicine, 2019 Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep.
Yue Zhang, Huizhu Qian, Jing Xu, Wen Gao
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ADARs regulate cuticle collagen expression and promote survival to pathogen infection [PDF]
BMC BiologyBackground In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection. The adenosine deaminase that act
Alfa Dhakal +5 more
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The role of ADAR1 through and beyond its editing activity in cancer [PDF]
Cell Communication and SignalingAdenosine-to-inosine (A-to-I) editing of RNA, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, is a prevalent RNA modification in mammals.
Yue Jiao +6 more
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ADARs have effects beyond RNA editing [PDF]
Cell Cycle, 2009 hairpin-mediated silencing and partially restores the red eye pigment. Inactive ADAR1p150 restored the pigmentation to 40% of ADAR1p150 levels suggesting that binding alone can influence processing of long duplexes into siRNAs. Cleavage by DICER is thought to be affected as this antagonism occurs in the cytoplasm and DICER can partially suppress the ...
Heale, Bret S E +2 more
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Chemical Modifications in RNA: Elucidating the Chemistry of dsRNA-Specific Adenosine Deaminases (ADARs). [PDF]
Acc Chem Res, 2023 Mendoza HG, Beal PA.
europepmc +3 more sources
PLoS Pathogens, 2022 ADARs (adenosine deaminases acting on RNA) are known for their adenosine-to-inosine RNA editing activity, and most recently, for their role in preventing aberrant dsRNA-response by activation of dsRNA sensors (i.e., RIG-I-like receptor homologs). However,
Dan Bar Yaacov
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