Results 21 to 30 of about 4,312 (239)
Frontiers in Pharmacology, 2022 Chemoresistance, especially temozolomide (TMZ) resistance, is a major clinical challenge in the treatment of glioblastoma (GBM). Exploring the mechanisms of TMZ resistance could help us identify effective therapies.
Can Lu +12 more
doaj +1 more source
Genome Biology, 2012 Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction.
Savva, Yiannis A +2 more
openaire +2 more sources
Journal of Experimental & Clinical Cancer Research, 2023 Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are subsequently recognized by the sensors of ...
Jing Yuan +5 more
doaj +1 more source
ADARs act as potent regulators of circular transcriptome in cancer
Nature Communications, 2022 RNA editing and circRNAs are involved in tumorigenesis. Here the authors report that ADARs regulate the circular transcriptome in a bidirectional manner through and beyond their editing function in multiple cancer cells.
Haoqing Shen +14 more
doaj +1 more source
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
core +1 more source
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]
, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik +3 more
core +2 more sources
Autocatalytic base editing for RNA-responsive translational control
Nature Communications, 2023 Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics.
Raphaël V. Gayet +9 more
doaj +1 more source
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. [PDF]
, 2015 Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Alon, S +10 more
core +2 more sources
RNA editing signature during myeloid leukemia cell differentiation [PDF]
, 2017 Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis +48 more
core +2 more sources
eLife, 2022 Adenosine deaminases acting on RNA (ADARs) can be repurposed to enable programmable RNA editing, however their exogenous delivery leads to transcriptome-wide off-targeting, and additionally, enzymatic activity on certain RNA motifs, especially those ...
Dhruva Katrekar +5 more
doaj +1 more source