Results 31 to 40 of about 4,312 (239)
Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing [PDF]
, 2012 Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein ...
Ales Balik +51 more
core +1 more source
ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
Cell Reports, 2013 Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang +5 more
doaj +1 more source
An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme [PDF]
, 2009 RNA editing by adenosine deamination is particularly prevalent in the squid nervous system. We hypothesized that the squid editing enzyme might contain structural differences that help explain this phenomenon. As a first step, a squid adenosine deaminase
O'Connell, Mary A +2 more
core +2 more sources
Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications
Non-Coding RNA, 2021 It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of
Venkata Naga Srikanth Garikipati +1 more
doaj +1 more source
Promoting RNA editing by ADAR attraction [PDF]
Genome Biology, 2017 Concentration is important and not only while driving; a new study indicates how an adjacent genomic element helps to increase the efficiency of a specific adenosine to inosine RNA editing reaction, by providing a means to increase the local concentration of the RNA editing enzyme ADAR.
Miri Danan-Gotthold, Erez Y. Levanon
openaire +3 more sources
BMC Genomics, 2018 Background A-to-I RNA editing is a co−/post-transcriptional modification catalyzed by ADAR enzymes, that deaminates Adenosines (A) into Inosines (I).
Edoardo Giacopuzzi +6 more
doaj +1 more source
Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core +1 more source
ADAR Editing Wobbles the MicroRNA World [PDF]
ACS Chemical Biology, 2007 Recent work reveals that adenosine-to-inosine editing occurs in a number of cellular microRNAs (miRNAs). Such editing is shown to diminish the expression of one miRNA and alter the target specificity of another. This changes our current views significantly by not only increasing the repertoire of miRNAs and their potential targets, but also providing ...
Asis K, Das, Gordon G, Carmichael
openaire +2 more sources
Grasping bulky objects with two anthropomorphic hands [PDF]
, 2016 © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new ...
Rojas de Silva Gonzalez, Francisco Abiud +1 more
core +1 more source
Conserved microRNA editing in mammalian evolution, development and disease. [PDF]
, 2014 BACKGROUND: Mammalian microRNAs (miRNAs) are sometimes subject to adenosine-to-inosine RNA editing, which can lead to dramatic changes in miRNA target specificity or expression levels.
Halbert, J. +4 more
core +3 more sources