PLoS ONE, 2023 Parkinson's Disease (PD) is the second most common neurodegenerative disease behind Alzheimer's Disease, currently affecting more than 10 million people worldwide and 1.5 times more males than females.
Heather Milliken Mercer +3 more
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The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing. [PDF]
, 2011 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Buchner, Erich +5 more
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8-azaadenosine and 8-chloroadenosine are not selective inhibitors of ADAR [PDF]
, 2021 Kyle A. Cottrell +2 more
openalex +1 more source
How do ADARs bind RNA? New protein‐RNA structures illuminate substrate recognition by the RNA editing ADARs [PDF]
BioEssays, 2017 Deamination of adenosine in RNA to form inosine has wide ranging consequences on RNA function including amino acid substitution to give proteins not encoded in the genome. What determines which adenosines in an mRNA are subject to this modification reaction?
Thomas, Justin M, Beal, Peter A
openaire +4 more sources
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Universal RNA editing in a human liver at the fetal stage [PDF]
, 2012 It is known that RNA editing occurs in human cells, which can change the information transmission from DNA to RNA and proteins. Most previous studies have focused on editing of the mRNAs. Here we reported that several kinds of RNAs, including miRNA, rRNA,
Chen, Huiping +4 more
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Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Knowledge in the Investigation of A-to-I RNA editing signals
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a post-transcriptional alteration of RNA sequences that is able to affect protein structure as well as RNA and protein expression. A-to-I (Adenosine-to-Inosine) RNA editing is the most frequent and common post-transcriptional modification ...
Giovanni eNigita +4 more
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Transient Cyclic Structured Oligonucleotide Designs for Therapeutic Applications
Current Protocols, Volume 6, Issue 2, February 2026.Abstract Oligonucleotide‐based therapeutics are now widely used in clinical settings. From the late 1980s to the mid‐1990s, efforts to improve therapeutic efficacy focused on imparting drug‐like properties to oligonucleotides, emphasizing nuclease stability and target sequence affinity.
Sudhir Agrawal
wiley +1 more source
Trade-off between transcriptome plasticity and genome evolution in cephalopods [PDF]
, 2017 Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Cell Press for personal use, not for redistribution.
Admon, Arie +9 more
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