Results 31 to 40 of about 97,234 (148)

Mechanisms of ADC Toxicity and Strategies to Increase ADC Tolerability

Cancers, 2023
Anti-cancer antibody-drug conjugates (ADCs) aim to expand the therapeutic index of traditional chemotherapy by employing the targeting specificity of monoclonal antibodies (mAbs) to increase the efficiency of the delivery of potent cytotoxic agents to malignant cells.
Toan D. Nguyen, Brandon M. Bordeau, Joseph P. Balthasar   +2 more
openaire   +2 more sources

In relapsed or refractory diffuse large B‐cell lymphoma, CD19 expression by immunohistochemistry alone is not a predictor of response to loncastuximab tesirine

eJHaem
CD19‐targeting treatments have shown promise in relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL). Loncastuximab tesirine (loncastuximab tesirine‐lpyl [Lonca]) is a CD19‐targeting antibody‐drug conjugate indicated for R/R DLBCL after at ...
Paolo F. Caimi, Mehdi Hamadani, Carmelo Carlo‐Stella, Masoud Nickaeen, Eric Jordie, Kiersten Utsey, Tim Knab, Francesca Zammarchi, Danilo Cucchi, Serafino Pantano, Karin Havenith, Ying Wang, Joseph Boni   +12 more
doaj   +1 more source

Outcomes with loncastuximab tesirine following CAR T-cell therapy in patients with relapsed or refractory diffuse large B-cell lymphoma

Blood Cancer Journal
The efficacy of loncastuximab tesirine (lonca) following chimeric antigen receptor T-cell therapy (CAR-T) progression/failure is unknown. Hence, we sought to examine real-world use and outcomes of lonca following CAR-T in patients with relapsed or ...
Narendranath Epperla, Melanie Lucero, Tom Bailey, Laura Mirams, Jolenta Cheung, Mona Amet, Gary Milligan, Lei Chen   +7 more
doaj   +1 more source

Apparent diffusion coefficient of water in evaluation of treatment response in animal body tumors

Біологічні студії, 2009
The review summarizes the author’s results and literature data on the evaluation of diffusion-weighted magnetic resonance imaging (DWI) as a cancer biomarkers that reflects structural, cellular, apoptotic, and necrotic changes in tumor tissue.
A. M. Babsky, Sh. Ju, N. Bansal
doaj   +1 more source

QSP modeling of loncastuximab tesirine with T-cell-dependent bispecific antibodies guides dose-regimen strategy

npj Systems Biology and Applications
Antibody-drug conjugates (ADCs) and T-cell-dependent bispecific antibodies (TDBs) show single-agent efficacy in relapsed/refractory (R/R) lymphomas.
Yuezhe Li, A. Katharina Wilkins, Jimena Davis, Timothy Knab, Marie Toukam, Joseph P. Boni, Daniel C. Kirouac   +6 more
doaj   +1 more source

Design of Intelligent Controller for Solar Tracking System Based on FPGA [PDF]

Engineering and Technology Journal, 2015
The needs for increasing the power generation make the use of solar cells plays an important role in the daily life. For this reason, it is important to use solar tracking system to increase or getting almost optimum amount from solar cells.
Hanan A. R. Akkar, Yaser M. Abid
doaj  

Dynamic range analysis of one-bit compressive sampling with time-varying thresholds

The Journal of Engineering, 2019
From the point of view of statistical signal processing, the dynamic range for one-bit quantisers with time-varying thresholds is studied. Maximum tolerable amplitudes, minimum detectable amplitudes and dynamic ranges of this one-bit sampling approach ...
Xiaofeng Zhu, Liang Huang, Ziqian Wang
doaj   +1 more source

Antibody Conjugates-Recent Advances and Future Innovations

Antibodies, 2020
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past 30 years. Clinical success rates of antibodies have exceeded expectations, resulting in heavy investment in biologics discovery and development in addition to ...
Donmienne Leung, Jacqueline M. Wurst, Tao Liu, Ruben M. Martinez, Amita Datta-Mannan, Yiqing Feng   +5 more
doaj   +1 more source

Study of the Diffusion Tensor Imaging for Preclinical Therapeutic Efficacy of Umbilical Cord Mesenchymal Stem Cell Transplantation in the Treatment of Spinal Cord Injury

International Journal of General Medicine, 2021
Ying Zhao,1,* Liqing Yao,1,* Lijuan Ao,2 Jibing Ou,1 Ying He,1 Yunyun Shang1 1The Second Affiliated Hospital of Kunming Medical University, Kunming, 650000, People’s Republic of China; 2School of Rehabilitation, Kunming Medical University ...
Zhao Y, Yao L, Ao L, Ou J, He Y, Shang Y
doaj  

Pipelined ADC based design of bandpass ΔΣ‐ADC

Electronics Letters, 2013
A high‐speed, large dynamic range f S /4 bandpass ΔΣ‐modulator using a first‐order error‐feedback loop is proposed. The internal quantiser is realised using a high‐speed pipelined ADC. Error feedback is achieved by exploiting the
V. Sarma, B. Sahoo
openaire   +1 more source