Results 41 to 50 of about 345,011 (278)

Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells

OncoImmunology, 2019
Oncology treatment has been revolutionized by the introduction of immune checkpoint inhibitor drugs, which enable 20–40% of patients to generate anti-tumor immune responses.
Maxine Bauzon, Penelope M. Drake, Robyn M. Barfield, Brandon M. Cornali, Igor Rupniewski, David Rabuka   +5 more
doaj   +1 more source

Research of data acquisition instrument based on domestic key chip

Dianzi Jishu Yingyong, 2022
The high performance data acquisition system is widely used in scientific research such as high energy physics, particle physics experiment and radiation detection, which is the key equipment of many large scientific experiment.
Zhao Qian, Luo Tongding, Chen Yanli, Wang Jing, Lv Zongjing, Li Haitao, Zhang Yanxia, Ruan Linbo   +7 more
doaj   +1 more source

Spectral Efficiency of Mixed-ADC Massive MIMO

, 2018
We study the spectral efficiency (SE) of a mixed-ADC massive MIMO system in which K single-antenna users communicate with a base station (BS) equipped with M antennas connected to N high-resolution ADCs and M-N one-bit ADCs.
Pirzadeh, Hessam, Swindlehurst, A. Lee
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Enhanced projectile path estimation using multi-vehicle FMCW radar sensors

Scientific Reports
This paper presents an enhanced approach to projectile path estimation using Frequency-Modulated Continuous Wave (FMCW) radar sensors distributed across multiple vehicles in a tactical formation.
Amgad A. Salama, Mahmoud A. Hussein
doaj   +1 more source

La libertad de expresión en Argentina y su comparación con la jurisprudencia de la Corte Interamericana: parecidos y diferencias entre los casos “Patitó” y “Kimel”

Anuario de Derechos Humanos, 2009
El presente comentario analiza, por una parte, los aspectos más relevantes de la sentencia de la Corte Suprema argentina en el caso Patitó, José Angel y otro c. Diario La Nación, del 24 junio de 2008.
Hernán Gullco
doaj   +1 more source

Longitudinal monitoring of Apparent Diffusion Coefficient (ADC) in patients with prostate cancer undergoing MR-guided radiotherapy on an MR-Linac at 1.5 T: a prospective feasibility study

Radiology and Oncology, 2023
Hybrid MRI linear accelerators (MR-Linac) might enable individualized online adaptation of radiotherapy using quantitative MRI sequences as diffusion-weighted imaging (DWI).
Almansour Haidara, Schick Fritz, Nachbar Marcel, Afat Saif, Fritz Victor, Thorwarth Daniela, Zips Daniel, Bertram Felix, Müller Arndt-Christian, Nikolaou Konstantin, Othman Ahmed E, Wegener Daniel   +11 more
doaj   +1 more source

Compressed Distributed Gradient Descent: Communication-Efficient Consensus over Networks [PDF]

, 2019
Network consensus optimization has received increasing attention in recent years and has found important applications in many scientific and engineering fields.
Bentley, Elizabeth, Liu, Jia, Zhang, Xin, Zhu, Zhengyuan, Zhu, Zhengyuan   +4 more
core   +4 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Development and implementation of a gyrolab-based generic anti-drug antibody assay for antibody-drug conjugates in cynomolgus monkey studies

Frontiers in Immunology
IntroductionNon-clinical immunogenicity yields valuable insights into pharmacokinetics, efficacy, and safety. Given the complex nature of ADC therapeutics, early detection of anti-drug antibodies (ADAs) is critical for elucidating exposure and toxicity ...
Runzhong Fu, Runzhong Fu, Christine O’Day, Razieh Esmaeili, Stavros Zinonos, Arlan Martin, Lisa McCulloch, Charles Y. Tan   +7 more
doaj   +1 more source