Results 51 to 60 of about 345,011 (278)

Effect of Renal Vein Variations on Apparent Diffusion Coefficient in Asymptomatic Patients

Haseki Tıp Bülteni, 2020
Aim:The aim of this study was to investigate whether renal vein variations had an effect on apparent diffusion coefficient (ADC) values in diffusion magnetic resonance imaging (MRI).Methods:Images of 958 patients who underwent MRI between January 2017 ...
Elif Gündoğdu, Emre Emekli, Mehmet Oğuzman, Mahmut Kebapçı   +3 more
doaj   +1 more source

More than Toxins—Current Prospects in Designing the Next Generation of Antibody Drug Conjugates

Frontiers in Bioscience-Landmark, 2022
Antibody drug conjugates (ADCs) are rapidly becoming a cornerstone in targeted therapies, especially for the treatment of cancer. Currently, there are 12 FDA-approved ADCs, eight of which have been approved within the last five years, with numerous ...
Jonathan Schwach, Mustafa Abdellatif, Andreas Stengl   +2 more
doaj   +1 more source

Contrast-free detection of myocardial fibrosis in hypertrophic cardiomyopathy patients with diffusion-weighted cardiovascular magnetic resonance. [PDF]

, 2015
BackgroundsPrevious studies have shown that diffusion-weighted cardiovascular magnetic resonance (DW-CMR) is highly sensitive to replacement fibrosis of chronic myocardial infarction. Despite this sensitivity to myocardial infarction, DW-CMR has not been
Bi, Xiaoming, Fan, Zhaoyang, Kellman, Peter, Li, Debiao, Lu, Minjie, Nguyen, Christopher, Zhao, Shihua   +6 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Measurements of accretion disc corona size in LMXB: consequences for Comptonization and LMXB models

, 2003
We present results of measurements of the radial extent of the accretion disc corona in low mass X-ray binaries. These results prove conclusively the extended nature of the ADC, with radial extent varying from 20,000 km in the faintest sources to 700,000
Abramowicz, Armitage, Barnard, Barret, Bałucińska-Church, Bałucińska-Church, Begelman, Begelman, Beloborodov, Chou, Christian, Church, Church, Church, Church, Church, Church, Church, Done, Eggleton, Fabian, Frank, Galeev, Gierliński, Haardt, Jimenez-Garate, Kluzniak, Liang, M. Bałucińska-Church, M. J. Church, Miller, Mitsuda, Morley, Narita, Narita, Nelson, Oosterbroek, Oosterbroek, Paczyński, Popham, Poutanen, Proga, Różańska, Różańska, Różańska, Shakura, Shakura, Shapiro, Sidoli, Smale, Smale, Walter, White, White, White, White, Woods, Zdziarski, Zdziarski   +58 more
core   +1 more source

In vivo contrast free chronic myocardial infarction characterization using diffusion-weighted cardiovascular magnetic resonance. [PDF]

, 2014
BackgroundDespite the established role of late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in characterizing chronic myocardial infarction (MI), a significant portion of chronic MI patients are contraindicative for the use of ...
Bi, Xiaoming, Dawkins, James, Dharmakumar, Rohan, Fan, Zhaoyang, Li, Debiao, Marbán, Eduardo, Nguyen, Christopher, Sharif, Behzad, Tseliou, Eleni, Xie, Yibin   +9 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Current ADC Linker Chemistry [PDF]

Pharmaceutical Research, 2015
The list of ADCs in the clinic continues to grow, bolstered by the success of first two marketed ADCs: ADCETRIS® and Kadcyla®. Currently, there are 40 ADCs in various phases of clinical development. However, only 34 of these have published their structures.
Jain, Nareshkumar, Smith, Sean W., Ghone, Sanjeevani, Tomczuk, Bruce   +3 more
openaire   +2 more sources

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Steady flow and dynamic analyses comparison of an air intake breathing capacity

MATEC Web of Conferences, 2017
Analysis of intake breathing capacity is important in order to determine the performance output for any respective engine. Flow coefficient and discharge coefficient are the common parameters used to define the breathing capability and different analysis
Mohamad Shafie Nur Adila, Muhamad Said Mohd Farid, Abdul Aziz Azhar, Abdul Latiff Zulkarnain, Mat Yamin Ahmad Kamal, Tamaldin Noreffendy   +5 more
doaj   +1 more source