Results 91 to 100 of about 45,703 (244)

HIV-Specific Antibody-Dependent Cellular Cytotoxicity (ADCC) -Mediating Antibodies Decline while NK Cell Function Increases during Antiretroviral Therapy (ART).

PLoS ONE, 2015
Understanding alterations in HIV-specific immune responses during antiretroviral therapy (ART), such as antibody-dependent cellular cytotoxicity (ADCC), is important in the development of novel strategies to control HIV-1 infection.
Sanne Skov Jensen, Anders Fomsgaard, Marie Borggren, Jeanette Linnea Tingstedt, Jan Gerstoft, Gitte Kronborg, Line Dahlerup Rasmussen, Court Pedersen, Ingrid Karlsson   +8 more
doaj   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

FcγRIIIa receptor polymorphism influences NK cell mediated ADCC activity against HIV

BMC Infectious Diseases, 2019
Background HIV-specific Antibody Dependent Cell Cytotoxicity (ADCC) has shown to be important in HIV control and resistance. The ADCC is mediated primarily by natural killer cell activated through the binding of FcγRIIIa receptor to the Fc portion of ...
Sneha Pramod Talathi, Nawaj Najir Shaikh, Sudhanshu Shekhar Pandey, Vandana Ashish Saxena, Megha Sunil Mamulwar, Madhuri Rajeev Thakar   +5 more
doaj   +1 more source

Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies [PDF]

, 2014
Recent immune correlates analysis from the RV144 vaccine trial has renewed interest in the role of non-neutralizing antibodies in mediating protection from infection.
A Trkola, AJ Hessell, AJ Hessell, AJ Hessell, AJ Hessell, AL DeVico, AM Sholukh, Anna Licht, Anne-Sophie Dugast, AS Dugast, B Moldt, BF Haynes, CT Ng, D Corti, Dan H. Barouch, DN Forthal, DN Forthal, DN Forthal, DR Burton, G Hashimoto, Galit Alter, Hendrik Streeck, Hualin Li, JM Binley, JM Binley, Joseph Nkolola, JR Bailey, JR Mascola, JR Mascola, LL Baum, LM Walker, Margaret E. Ackerman, MD Simek, Michelle Hoffner, MM Aasa-Chapman, Musie Ghebremichael, ND Banks, O Alsmadi, O Lambotte, P Xiao, PW Parren, R Hidajat, R Hofmann-Lehmann, RH Florese, RH Florese, S Kohl, S Rerks-Ngarm, S Russo, Shan Lu, T Moore, Todd J. Suscovich, TW Baba, V Holl, VR Gomez-Roman, VR Gomez-Roman, X Wei, Y Kaneko, Ying Chan   +57 more
core   +3 more sources

Molecular crosstalk via exosomes in lung cancer progression

Interdisciplinary Medicine, EarlyView.
“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan   +3 more
wiley   +1 more source

Submandibular and sublingual salivary gland involvement in adenoid cystic carcinoma

Autopsy and Case Reports
Adenoid cystic carcinoma (AdCC) is a malignant salivary gland neoplasm that presents as an indolent but aggressive neoplasm. AdCC histogenesis is linked to the intercalated ducts of the salivary glands, equally affecting the major and minor glands. AdCC
Poonam Ramnath Sawant, Manjeeta Mahesh Sinai Dhume, Anita Spadigam, Anita Dhupar   +3 more
doaj   +1 more source

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. [PDF]

, 2015
The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL).
Ale-Ali, Amine, Amaya-Chanaga, Carlos I, Cardarelli, Pina M, Castro, Januario E, Choi, Michael Y, Cohen, Lewis J, Jones, Harrison, Kashyap, Manoj K, Kipps, Thomas J, Kuhne, Michelle R, Kumar, Deepak, Melo-Cardenas, Johanna, Rassenti, Laura Z, Sabbatini, Peter, Shelat, Suresh G   +14 more
core   +2 more sources

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Model and distribution uncertainty in multivariate GARCH estimation: a Monte Carlo analysis [PDF]

Multivariate GARCH models are in principle able to accommodate the features of the dynamic conditional correlations processes, although with the drawback, when the number of financial returns series considered increases, that the parameterizations entail
Rossi, Eduardo, Spazzini, Filippo
core   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source