Results 81 to 90 of about 27,022 (204)

Circulating Natural Killer Cells in Patients With Type 2 Diabetes and Peripheral Neuropathy Are Altered in Their Frequency and Exhibit Impaired Functions and Angiogenic Activities

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Neuropathic T2DM is characterized by increased circulating NK‐cell frequency but impaired NK‐cell function. Functional defects, including reduced degranulation and diminished pro‐angiogenic activity, together with an inflammatory cytokine milieu, promote macrophage recruitment, vascular inflammation, and defective angiogenesis, highlighting NK‐cell ...
Maria Teresa Palano, Federica Riccio, Luisa Sambado, Elena Tagliabue, Milena Bertolotti, Marzia Campanile, Martina Mutoli, Fiorenza Lotti, Andrea Rampin, Cristian Rubuano, Giorgia Maspero, Antonio Antico, Francesca Pitzalis, Matteo Fassan, Piero Maria Stefani, Paola Ostano, Giovanna Chiorino, Nicolò Baranzini, Laura Pulze, Annalisa Grimaldi, Antonino Bruno, Maria Sambataro, Gaia Spinetti   +22 more
wiley   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, Volume 2, Issue 5, October 2026.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Autoantibodies to Extracellular Erythrocyte Band 3 Epitopes Are Associated With Anemia in Plasmodium vivax Infection

American Journal of Hematology, Volume 101, Issue 10, Page 2592-2604, October 2026.
ABSTRACT Plasmodium vivax‐associated anemia is a multifactorial clinical outcome, in which the destruction of uninfected red blood cells (uRBCs) plays a major role in disease development and severity. Here, we identified autoantibody targets within the extracellular loops of Band 3 (B3), a major erythrocyte transmembrane protein.
Aline Marzano‐Miranda, Vanessa G. Fraga, Cor Jésus F. Fontes, Simone Ladeia‐Andrade, Marcelo U. Ferreira, Daniella C. Bartholomeu, Érika M. Braga   +6 more
wiley   +1 more source

Anti-CD137 monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression.

PLoS ONE, 2018
Because human epidermal growth factor-like receptor (HER) 2 is expressed on the surface of human pancreatic carcinoma cells to varying degrees, trastuzumab, an anti-HER2 monoclonal antibody (mAb), is expected to exert antibody-dependent, natural killer ...
Takushi Masu, Masanori Atsukawa, Katsuhisa Nakatsuka, Masumi Shimizu, Daishu Miura, Taeang Arai, Hirotomo Harimoto, Chisa Kondo, Keiko Kaneko, Seiji Futagami, Chiaki Kawamoto, Hidemi Takahashi, Katsuhiko Iwakiri   +12 more
doaj   +1 more source

Optimizing the ER Cutoff in HER2‐Positive Breast Cancer: ER ≥ 50% Predicts Low pCR Rates and Resistance to Antibody‐Drug Conjugates in the Neoadjuvant Setting

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Estrogen receptor (ER)‐positive/HER2‐positive breast cancer demonstrates significantly lower rates of pathological complete response (pCR) to neoadjuvant HER2‐targeted therapies compared to ER‐negative/HER2‐positive disease. However, the optimal ER positivity cutoff for clinically meaningful patient stratification remains undefined.
Tian Du, Min Lin, Gehao Liang, Yan Wang, Hao Wu, Zixuan Zhao, Luhao Sun, Jun Tang   +7 more
wiley   +1 more source

ADCC: the rock band led by therapeutic antibodies, tumor and immune cells

Frontiers in Immunology
Antibody-dependent cellular cytotoxicity (ADCC) is a critical mechanism by which therapeutic antibodies leverage the immune system to target and eliminate cancer cells. The key agents of ADCC are natural killer (NK) cells, specifically targeting antibody-
Roos Vincken, Roos Vincken, Uxue Armendáriz-Martínez, Ana Ruiz-Sáenz, Ana Ruiz-Sáenz   +4 more
doaj   +1 more source

Coordinated TNF–NF‐κB and PI3K–Akt Modulation by Yueju Pill in Hashimoto's Thyroiditis: A Network Pharmacology and Molecular Docking Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Network pharmacology and molecular docking identify a coordinated dual‐axis regulatory framework for Yueju pill in Hashimoto's thyroiditis. Candidate compounds and prioritized targets converge on TNF–NF‐κB inflammatory and PI3K–Akt survival/apoptosis signaling, providing computational support for a testable multi‐target hypothesis requiring ...
Hao Zhang, Kuojun Ren, Shengying Wang
wiley   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source

CLDN18.2 in pancreatic ductal adenocarcinoma: Biomarker assessment, spatial heterogeneity and therapeutic modality selection

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review presents a framework for selecting Claudin 18.2 (CLDN18.2)‐directed treatment modalities in pancreatic ductal adenocarcinoma according to tumour antigen coverage and spatial distribution. Representative assessment at baseline and reassessment after progression can guide treatment adaptation over time.
Ruyu Tan, Zhexin Zhang, Jiaxin Wang, Roland Andersson, Daniel Ansari, Jinfei Chen   +5 more
wiley   +1 more source

Context‐dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Divergent triggering receptor expressed on myeloid cells 2 (TREM2) signalling pathways instruct myeloid cell adaptation towards neuroprotective disease‐associated microglia (DAM)/lipid‐associated macrophage (LAM) or immunosuppressive tumour‐associated macrophage (TAM) phenotypes.
Yaqing Lv, Mingpeng Shi, Yongfei Zhao, Yi Yu, Jiawei Lv, Hai Zhao   +5 more
wiley   +1 more source