Results 131 to 140 of about 45,703 (244)

Antenatal risk estimation for exchange transfusions in neonates with hemolytic disease of the fetus and newborn in a changing treatment landscape: A multicenter, retrospective cohort study

Transfusion, EarlyView.
Abstract Background Neonates with hemolytic disease of the fetus and newborn (HDFN) may require exchange transfusions (ET) for severe hyperbilirubinemia. We evaluated if ET in neonates with HDFN was associated with the maximum maternal titer and antibody‐dependent cellular cytotoxicity (ADCC) and we determined the change in the number of hospitals ...
Derek P. de Winter, Masja de Haas, Christian V. Hulzebos, Michaël V. Lukens, Sandra A. Prins, Jasper V. Been, Esther J. d'Haens, Daniël C. Vijlbrief, Sabine L. A. G. Vrancken, Amanda M. P. Trompenaars, Huib Ceelie, Lieke M. J. van Zogchel, Annemiek M. C. P. Joosen, Clemens B. Meijssen, J. L. A. M. van Hillegersberg, Janneke C. Zant, Maaike C. van Rossem, Ron van Beek, Helene G. Stas, Clare E. Counsilman, F. R. Knol, I. A. M. Schiering, Gerdina H. Dubbink‐Verheij, E. J. T. Verweij, Enrico Lopriore, for the WISE investigators, Ron van Beek, A.J. (Adriaan) van Gammeren, Sandra A. Prins, J.H. Klinkspoor, Jasper V. Been, Henk Russcher, Clare E. Counsilman, Sietske Hogenboom, Huib Ceelie, Angelique Hoffmann‐Haringsma, Gerdina H. Dubbink‐Verheij, Jacques J.H. Hens, Esther J. d'Haens, Gijs den Besten, Lieke M.J. van Zogchel, N.C.V. Péquériaux, Derek P. de Winter, E.J.T. (Joanne) Verweij, Masja de Haas, Enrico Lopriore, Helene G. Stas, Floor Weerkamp, Amanda M.P. Trompenaars, Tinta J.F. Lebon, Annemiek M.C.P. Joosen, Peter Andriessen, Clemens B. Meijssen, Karlijn Gijzen, F.R. Knol, Janneke C. Zant, Geert Jan Blok, Sabine L.A.G. Vrancken, Annegeet van den Bos, Maaike C. van Rossem, Jolanda Lamberts, I.A.M. Schiering, Claudia Admiraal, J.L.A.M. van Hillegersberg, Daniël C. Vijlbrief, Karen M.K. De Vooght, Christian V. Hulzebos, Michaël V. Lukens   +67 more
wiley   +1 more source

IgG4 anti‐CD47: Erythrophagocytosis and potential transfusion complications

Transfusion, EarlyView.
Abstract Background IgG4 monoclonal anti‐CD47 for cancer immunotherapy resulted in anemia necessitating red cell (RBC) transfusions. Although the antibody readily binds to CD47 on RBCs, the mechanism underlying the anemia associated with IgG4 is poorly understood.
Kayluz Frias Boligan, Melika Loriamini, Mairead B. Holton, Gurleen Sandhu, Beth Binnington, Randall Velliquette, Connie M. Westhoff, Donald R. Branch   +7 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

The spectrum of breast in situ papillary carcinomas with invasion and invasive breast carcinomas with papillary features: an overview of histological subtypes and diagnostic challenges

Histopathology, Volume 88, Issue 4, Page 747-768, March 2026.
Invasive breast carcinomas with papillary features (IBCP) comprise diverse subtypes with variable architecture, histopathology, and clinical behaviour. This review outlines evolving classification, diagnostic criteria, and treatment implications, highlighting challenges in distinguishing in situ from invasive lesions. Standardised diagnostic approaches
Emad A Rakha, Puay Hoon Tan, Wendy A Raymond   +2 more
wiley   +1 more source

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe, Tamara Zoran, Marylyn Martina Addo   +2 more
wiley   +1 more source

Model Averaging and Value-at-Risk Based Evaluation of Large Multi Asset Volatility Models for Risk Management [PDF]

This paper considers the problem of model uncertainty in the case of multi-asset volatility models and discusses the use of model averaging techniques as a way of dealing with the risk of inadvertently using false models in portfolio management.
M. Hashem Pesaran, Paolo Zaffaroni
core  

Development of tCAP(N3): Affinity Peptide‐Aided, pH‐Triggered Strategy for Site‐Specific Native IgG Modification

Chemistry – A European Journal, Volume 32, Issue 6, 9 February 2026.
The tCAP(N3) reagent, featuring a stable and self‐activating precursor, enables site‐specific conjugation of native IgGs. This Fc‐affinity peptide approach selectively transfers an Ac‐Lys(N3)‐Gly‐Gly payload to Lys248, producing divalently azidated antibody while preserving its biological function.
Hiroko Kawakami, Abdur Rafique, Shugo Tsuda, Asaki Nagashima, Yukie Nohara, Naoki Dozono, Ken Sakamoto, Shun Masuda, Masato Kiyoshi, Hiroko Shibata, Akiko Ishii‐Watabe, Taku Yoshiya, Yuji Ito   +12 more
wiley   +1 more source

Valuing Volatility Spillovers [PDF]

forecasting, adcc, volatility spillovers ...
George Milunovich, Susan Thorp
core  

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source