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Development of a Macrophage-Based ADCC Assay [PDF]
Vaccines, 2021 Fc-dependent effector functions are an important determinant of the in vivo potency of therapeutic antibodies. Effector function is determined by the combination of FcRs bound by the antibody and the cell expressing the relevant FcRs, leading to antibody-dependent cellular cytotoxicity (ADCC).
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Use of microcalorimetry in analysing the kinetics of ADCC
Journal of Immunological Methods, 1986Microcalorimetry was found to be a useful technique for the demonstration of antibody-dependent cellular cytotoxicity (ADCC) against human melanoma cells mediated by a heterologous rabbit antiserum and two monoclonal antibodies in combination with human peripheral blood lymphocytes as effector cells.
J, Ankerst, H O, Sjögren, R, Fäldt
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1995
Abstract Infection with HIV-1 (or HIV-2 or SIV) induces initial and long-lasting high levels of MHC class I restricted CD8-positive cytotoxic T lymphocytes (CTL) which interact through their specific T cell receptors (TCRs) with processed viral fragments (peptides) presented on the surface of infected cells in association with an MHC ...
Frances Gotch, Kristina Broliden
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Abstract Infection with HIV-1 (or HIV-2 or SIV) induces initial and long-lasting high levels of MHC class I restricted CD8-positive cytotoxic T lymphocytes (CTL) which interact through their specific T cell receptors (TCRs) with processed viral fragments (peptides) presented on the surface of infected cells in association with an MHC ...
Frances Gotch, Kristina Broliden
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The Utility of ADCC Responses in HIV Infection
Current HIV Research, 2008Simple antibodies or vector-induced T cell immunity are unable to provide broad immunity to HIV. Although broadly reactive neutralising antibodies are a goal of vaccination, this remains elusive. There is growing evidence that HIV-specific antibodies that mediate their activity via the Fc-receptor, such as antibody dependent cellular cytotoxicity (ADCC)
Amy, Chung +4 more
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Associative Recognition in ADCC
1982In ADCC, recognition of the target cells is mediated by IgG antibodies. Available evidence also suggests that target cell lysis is triggered by the interaction of Fc structures of the inducing IgG with the Fcγ-receptors of the killer cell (1). Target cell recognition and triggering of lysis would thus appear to be linked but independent reactions.
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ADCC activity of monoclonal anti-D antibodies
Revue Francaise de Transfusion et Immuno-hématologie, 1988The present study compares the ability of 19 monoclonal anti-Rh antibodies with polyclonal anti-D sera and with anti-D immunoglobulin preparations as to their activity to mediate red cell (RBC) destruction.
S J, Urbaniak, G M, Stewart
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Critical evaluation of the ADCC test.
Archivum immunologiae et therapiae experimentalis, 1987The activity of monocytes in the ADCC test against human red blood cells sensitized with anti-Rh antibodies is unquestionable, however, a participation of lymphocytes in this reaction is still controversial. The aim of this paper was to test the cytotoxic activity of monocytes and lymphocytes isolated from human peripheral blood against erythrocytes ...
E, Brojer, B, Górska
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Enhancement of human ADCC with interferon.
Clinical and experimental immunology, 1983We have studied the ability of a purified preparation of leucocyte interferon (IF) to augment human antibody-dependent cell-mediated cytotoxicity (ADCC). The IF preparation was added to cultures of the ADCC assay consisting of peripheral blood mononuclear target cells, a sensitizing human antiserum specific for the HLA antigens expressed on the target ...
R, Warren, D, Kalamasz, R, Storb
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The effect of interferon on ADCC (I).
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology, 1984The effect of human leukocyte interferon (Hu INF alpha) on antibody-dependent cell-mediated cytotoxicity against antibody-treated chicken red blood cells was studied. Peripheral blood mononuclear cells were not significantly stimulated by IFN in ADCC. The lymphocytes freed from adherent cells, however, were more cytotoxic when IFN-treated, than without
N, Spangsbjerg, I, Heron
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