Results 91 to 100 of about 2,367,237 (341)

Additive Manufacturing of Ceramics [PDF]

eCAADe proceedings, 2019
Additive manufacturing (AM) is vastly developing across the industrial landscape and has recently expanded outside of the traditional polymeric and metallic-based materials. Ceramics are an ever-present material in the architectural field, but there has been minimal evolution in its associated manufacturing processes.
openaire   +2 more sources

Additive manufacturing of magnesium alloys

Bioactive Materials, 2020
Magnesium alloys are a promising new class of degradable biomaterials that have a similar stiffness to bone, which minimizes the harmful effects of stress shielding. Use of biodegradable magnesium implants eliminates the need for a second surgery for repair or removal.
Rakeshkumar Karunakaran, Sam Ortgies, Ali Tamayol, Florin Bobaru, Michael P. Sealy   +4 more
openaire   +3 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Influence of Recoater Speed on Powder Bed and Part Quality in Powder Bed Fusion of Metals Using a Laser Beam

Metals
The powder bed fusion of metals using a laser beam (PBF-LB/M) is an additive manufacturing process for the direct production of metal parts using powder as a starting material.
Nick Hantke, Tim Robert Brocksieper, Tobias Grimm, Jan T. Sehrt   +3 more
doaj   +1 more source

In process monitoring of the thermal profile during solidification in laser directed energy deposition of aluminium

Additive Manufacturing Letters, 2022
The manufacturing of parts in a layer-by-layer fashion in laser based directed energy deposition (L-DED) of wire enables a unique flexibility and freedom of part design, but some technological challenges remain unsolved.
Christian Hagenlocher, Patrick O’Toole, Wei Xu, Milan Brandt, Mark Easton, Andrey Molotnikov   +5 more
doaj  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

In situ observation and reduction of hot-cracks in laser additive manufacturing

Communications Materials
Cracking during Laser Additive Manufacturing is a problem for many higher-strength aluminium alloys, including AA6061. Here, we used a pulsed laser with ramp-down power modulation to improve the cracking resistance by about 50% compared to the use of a ...
Yunhui Chen, Duyao Zhang, Patrick O’Toole, Dong Qiu, Marc Seibold, Klaus. Schricker, Jean-Pierre Bergmann, Alexander Rack, Mark Easton   +8 more
doaj   +1 more source

On the development of twinning-induced plasticity in additively manufactured 316L stainless steel

Additive Manufacturing Letters, 2023
A report on twinning-induced plasticity in 316L stainless steel manufactured by metal additive manufacturing (AM) is presented. A tapered tensile test geometry was used which enabled the investigation of twin formation over a range of strain levels in a ...
D. Della Crociata, I. Maskery, R. Hague, M. Simonelli   +3 more
doaj  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source