Results 111 to 120 of about 2,663,019 (338)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Deep Learning for Additive Manufacturing-driven Topology Optimization

, 2022
Waad Almasri, Florence Danglade, Dimitri Bettebghor, Faouzi Adjed, Fakhreddine Ababsa   +4 more
openalex   +1 more source

Additive Manufacturing of Heat Exchangers in Aerospace Applications: A Review

Applied Thermal Engineering, 2023
Francesco Careri, R. Khan, Catherine Todd, Moataz M. Attallah   +3 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The Chinese Knot inspired anisotropic TC4 lattice Structures: Ultra-high specific strength in engineering materials

Materials & Design
Lattice structures possess high specific strength, multi-functionality through innovative structural designs. Here, we proposed an efficient method for the construction of lattice structures by elongating two-dimensional planar patterns along the load ...
Shenghang Xu, Chao Ding, Meng Han, Minghao Huang, Chunnan Song, Chen Chang, Shiqiu Liu, Xin Yang, Huiping Tang   +8 more
doaj   +1 more source

Porous composite with negative thermal expansion obtained by photopolymer additive manufacturing

, 2015
Additive manufacturing (AM) could be a novel method of fabricating composite and porous materials having various effective performances based on mechanisms of their internal geometries.
Kitamura, Mitsuru, Kobashi, Makoto, Takezawa, Akihiro   +2 more
core   +2 more sources

Phenolic Carbon Fiber Composite Inks for the Additive Manufacturing of Carbon/Carbon (C/C)

, 2023
Caitlyn M. Clarkson, William J. Costakis, Andrew Abbott, Andrew Schlup, Connor Wyckoff, James W. Kemp, Lisa M. Rueschhoff, Matthew T. Dickerson, Hilmar Koerner   +8 more
openalex   +1 more source

Review on field assisted metal additive manufacturing

International journal of machine tools & manufacture, 2023
Chao-lin Tan, Runsheng Li, Jinlong Su, Dafan Du, Yang Du, B. Attard, Y. Chew, Haiou Zhang, E. Lavernia, Y. Fautrelle, Jie Teng, A. Dong   +11 more
semanticscholar   +1 more source