Results 81 to 90 of about 567,714 (357)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Defect detection by multi-axis infrared process monitoring of laser beam directed energy deposition

Scientific Reports
Laser beam directed energy deposition (DED-LB) is an attractive additive manufacturing technique to produce versatile and complex 3D structures on demand, apply a cladding, or repair local defects.
T. Herzog, M. Brandt, A. Trinchi, A. Sola, C. Hagenlocher, A. Molotnikov   +5 more
doaj   +1 more source

Designing heterogeneous porous tissue scaffolds for additive manufacturing processes [PDF]

, 2013
A novel tissue scaffold design technique has been proposed with controllable heterogeneous architecture design suitable for additive manufacturing processes.
Khoda, AKM Bashirul, Koc, Bahattin, Koç, Bahattin, Ozbolat, Ibrahim T., Özbolat, İbrahim T.   +4 more
core   +1 more source

Singularity-aware motion planning for multi-axis additive manufacturing [PDF]

arXiv, 2021
Multi-axis additive manufacturing enables high flexibility of material deposition along dynamically varied directions. The Cartesian motion platforms of these machines include three parallel axes and two rotational axes. Singularity on rotational axes is a critical issue to be tackled in motion planning for ensuring high quality of manufacturing ...
arxiv  

Additively manufactured ultra-high vacuum chamber below $10^{-10}$ mbar [PDF]

Additive Manufacturing 40, 101898 (2021), 2019
Metal-based additive manufacturing (AM) represents a paradigm change in engineering and production methods across multiple industries and sectors. AM methods enable mass reduction and performance optimisation well beyond that achievable via conventional manufacturing, thereby impacting significantly on aerospace and space technologies.
arxiv   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

A method to assess the application of additive manufacturing to inventory replenishment : a thesis presented in partial fulfilment of the requirements for the Master of Supply Chain Management at Massey University, Albany, New Zealand [PDF]

, 2018
Companies have historically struggled to deal with their stock, especially the long inventory tail. As most of the inventory management techniques that deal with slow-moving stock have proved to be rather inefficient, this research investigates the use ...
Fonseca Garcia, Raphael da
core  

Additive manufacturing: state-of-the-art and application framework [PDF]

, 2017
Additive manufacturing encompasses a class of production processes with increasing applications in different areas and supply chains. Due to its flexibility for production in small batches and the versatility of materials and geometries, this technology ...
de Senzi Zancul, Eduardo, Gonçalves Mançanares, Cauê, Mezzeti Giordano, Caio, Rodrigues, Vinicius Picanco, Sergio Salerno, Mario   +4 more
core   +4 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Effect of TiB₂ Addition on the Microstructure and Mechanical Properties of Laser-Directed Energy Deposition TiAl Alloy

Metals
The microstructure characteristics of TiAl alloy prepared by laser-directed energy deposition (L-DED) are coarse columnar grains parallel to the building direction, which results in serious mechanical properties and anisotropy and limits its application.
Yancheng Yang, Yi Hu, Hongyan Chen, Yu Li, Jiawei Wang, Xu Cheng, Haibo Tang, Xianzhe Ran, Dong Liu   +8 more
doaj   +1 more source