Results 151 to 160 of about 401,272 (328)
Studies on cultured coronary endothelial cells [PDF]
, 1980 Gerbes, Alexander L. +3 more
core +1 more source
Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss
Advanced Science, EarlyView.In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang +20 more
wiley +1 more source
GLYCINE AND ADENINE AS PRECURSORS OF NUCLEIC ACID PURINES IN TUMOR-BEARING MICE
, 1955 Ralph K. Barclay, Esther Garfinkel
openalex +1 more source
Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity
Advanced Science, EarlyView.SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li +8 more
wiley +1 more source
REVERSIBLE ENZYMATIC SYNTHESIS OF FLAVIN-ADENINE DINUCLEOTIDE
, 1950 Anthony W. Schrecker, Arthur Kornberg
openalex +1 more source
The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver [PDF]
, 1967 DH Williamson, P. Kay Lund, HA Krebs
openalex +1 more source
A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing
Advanced Science, EarlyView.This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang +17 more
wiley +1 more source
Advanced Science, EarlyView.MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang +13 more
wiley +1 more source
THE DIRECT CONTRIBUTION OF ADENINE TO THE BIOGENESIS OF RIBOFLAVIN BY EREMOTHECIUM ASHBYII
, 1954 Walter S. McNutt
openalex +1 more source
Advanced Science, EarlyView.FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou +8 more
wiley +1 more source