Results 141 to 150 of about 252,905 (308)

Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study

Open Veterinary Journal
Background: Adenine is a naturally occurring purine essential for life, but its excess intake can cause metabolic disturbances leading to cardiovascular complications, renal stones, gout, fatigue, and anemia.
Waleed Khaled Y. Albahadly, Mohammed Jasim Jawad, Mohammed Ibrahim Rasool, Haider Falih ShamikhAl-Saedi, Asia Ali Hamza   +4 more
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection [PDF]

The increasing trend of cardiac diseases is becoming a major threat globally. Cardiac activities are based on integrated action potential through electronic flux changes within intra- and extracellular molecular activities.
Md Sahidul Arefin, Sudip Kumar Das, Fazle Kibria   +2 more
core   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Time Resolved DNA Barcodes for Information Encoding and Dynamic Encryption

Advanced Science, EarlyView.
This study establishes a molecular information platform based on DNA Temporal Barcodes. Information is encoded through combinations of DNA tags with distinct retention times, while dynamic encryption is achieved through a key‐triggered DNA ligation.
Likang Chu, Haixia Wang, Haiyan Gao, Sixian Chen, Zilong Li, Zhanyihao Hao, Lei He, Da Han   +7 more
wiley   +1 more source

Adenine specific DNA chemical sequencing reaction [PDF]

, 1987
Reaction of DNA with K^PdCLt at pH 2.0 followed by a piperidine workup produces specific cleavage at adenine (A) residues. Product analysis revealed the K^PdCU reaction involves selective depurination at adenine, affording an excision reaction analogous ...
Iverson, Brent L., Dervan, Peter B., Brent L. Iverson, Peter B. Dervan   +3 more
core  

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health
Chronic kidney disease (CKD) is projected to become the fifth most prevalent chronic disease globally. Establishing a reliable animal model is essential for advancing prevention and treatment strategies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
doaj   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

The physio-histological improvement of CeO2NPs and calcitriol treatment on inflamed chronically kidneys in male laboratory rats

Medical Journal of Babylon
Background: Chronic kidney disease affects almost 10% of the world, according to current studies. The complications of chronic renal disease can lead to mortality.
Asawer Kareem ALsadoon, Jafar Abass Issa Al-Maamori, Ahmed Mahdi Rheima   +2 more
doaj   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source