Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Activation of a differentiation‐inducing protein by adenine and adenine containing nucleotides [PDF]
FEBS Letters, 1971 Landau, Tamar, Sachs, Leo
openaire +2 more sources
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Heat-Killed <i>Lacticaseibacillus paracasei</i> HY2782 Attenuates Chronic Kidney Disease by Suppressing Inflammation and Selectively Modulating the Gut Microbial Community. [PDF]
J Microbiol BiotechnolKim H +4 more
europepmc +1 more source
Effect of endogenous adenosine augmentation on ischemia and reperfusion injury to the liver [PDF]
, 1997 Ishizaki, N +8 more
core +1 more source
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
Investigation of the cortical bone metabolome of C57BL/6J mice with adenine-induced kidney disease. [PDF]
JBMR PlusStauffer S +6 more
europepmc +1 more source
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
AcuB senses cellular energy charge to coordinate acetyl-CoA synthesis in bacteria. [PDF]
Nat CommunJanetzky M +16 more
europepmc +1 more source