Results 171 to 180 of about 417,743 (333)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

A High Fat/High Sucrose Diet Alters the Skeletal Response to Adenine-Induced Chronic Kidney Disease in Male Rats. [PDF]

Calcif Tissue Int
Metzger CE, Tak LY, LaPlant AN, Allen MR.   +3 more
europepmc   +1 more source

Purine metabolism in cultured endothelial cells [PDF]

, 1980
Gerbes, Alexander L., Gerlach, E., Nees, S., Sperling, Oded, Willershausen, B.   +4 more
core   +1 more source

Improving the Skin‐Conformability of Wearable Continuous Glucose Monitors With Synthetic Hydrogel Electrodes

Advanced Science, EarlyView.
A synthetic hydrogel electrode for skin‐conformable enzymatic biosensing is presented, featuring a stretchable, tape‐shaped continuous glucose monitor for non‐invasive diabetes management. ABSTRACT Synthetic bioelectronics is rapidly advancing, propelled by breakthroughs in synthetic biology and bioelectronics.
Binbin Cui, Shilei Dai, Ivo Pang, Dingyao Liu, Xinran Zhang, Jing Bai, Xinyu Tian, Shiming Zhang   +7 more
wiley   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Effects of Folate and Fructose Intakes on Renal Cytokines and Fibrosis in an Adenine-Induced Mouse Model of Chronic Kidney Disease. [PDF]

Int J Mol Sci
Chen TY, Chiu YC, Lin BF.
europepmc   +1 more source

Adenine [PDF]

, 2019
openaire   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis. [PDF]

BMC Cardiovasc Disord
Hense N, Stein M, Marx N, Kaesler N, Goettsch C.   +4 more
europepmc   +1 more source

[6N]METHYL ADENINE IN THE NUCLEAR DNA OF A EUCARYOTE, TETRAHYMENA PYRIFORMIS [PDF]

, 1973
Martin A. Gorovsky, Stanley Hattman, Gloria L. Pleger   +2 more
openalex   +1 more source