Results 171 to 180 of about 487,247 (373)

i-Silence, Please! An Alternative for Gene Disruption via Adenine Base Editors

, 2020
Hyeon‐Ki Jang, Sangsu Bae
openalex   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

The pAblo · pCasso self-curing vector toolset for unconstrained cytidine and adenine base-editing in Gram-negative bacteria [PDF]

Ekaterina Kozaeva, Zacharias S. Nielsen, Manuel Nieto‐Domínguez, Pablo I. Nikel   +3 more
openalex   +1 more source

Shoot induction using Benzyl Adenine in three accessions of patchouli plant (Pogostemon cablin Benth) from West Pasaman

, 2020
Eliza Mayura, Gustian Gustian, Renni Mayerni   +2 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Fluorogenic Reaction of Adenine with α-Hydroxyaldehyde

, 1975
MANKI PARK, Haruko Isemura, Hidetaka Yuki, Kiyoshi Takiura   +3 more
openalex   +2 more sources

The pAblo·pCasso self-curing vector toolset for unconstrained cytidine and adenine base-editing in Gram-negative bacteria [PDF]

, 2023
Ekaterina Kozaeva, Zacharias S. Nielsen, Manuel Nieto‐Domínguez, Pablo I. Nikel   +3 more
openalex   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

Quantification of Antibiotic Diffusion in Biofilms Using Gold Nanostar Surface‐enhanced Raman Spectroscopy

Advanced Science, EarlyView.
Gold nanostar‐enhanced Raman spectroscopy (SERS) enables real‐time, label‐free tracking of levofloxacin diffusion in intact biofilms. Nanostars embedded 16 µm below the surface detect drug arrival over time, revealing the impact of the biofilm matrix on antibiotic transport. Abstract The increased resistance to antibiotics shown by bacteria in biofilms
Wafaa Aljuhani, Yingrui Zhang, Matthew P. Wylie, Colin P. McCoy, Steven E. J. Bell   +4 more
wiley   +1 more source

Effects of CH₃OH and NH₃ on the Hydrolytic Deamination Mechanismof Adenine [PDF]

, 2010
Haiying Liu, Fancui Meng, Ping Li, Shiliang Ding   +3 more
openalex   +1 more source