Results 61 to 70 of about 401,272 (328)

The impact of altered dietary adenine concentrations on the gut microbiota in Drosophila

Frontiers in Microbiology
The gut microbiota influences host metabolism and health, impacting diseases. Research into how diet affects gut microbiome dynamics in model organisms is crucial but underexplored. Herein, we examined how dietary adenine affects uric acid levels and the
Xianglin Yin, Xianglin Yin, Qing Tong, Jingtao Wang, Jinfeng Wei, Zhenbo Qin, Yujie Wu, Ruidi Zhang, Baosheng Guan, Hongbin Qiu, Hongbin Qiu   +10 more
doaj   +1 more source

Hydro-chemical study of the evolution of interstellar pre-biotic molecules during the collapse of molecular clouds

, 2012
One of the stumbling blocks for studying the evolution of interstellar molecules is the lack of adequate knowledge of the rate co-efficients of various reactions which take place in the Interstellar medium and molecular clouds.
Ankan Das, Boogert, Chakrabarti, Chakrabarti, Chakrabarti, Cuppen, Das, Fuente, Gibb, Guelin, Ioppolo, Kuan, Liton Majumdar, Sandip K. Chakrabarti, Snyder, Sonali Chakrabarti, Woon   +16 more
core   +1 more source

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N, Jin, MB, Kawashima, Y, Shimamura, T, Starzl, TE, Todo, S, Totsuka, E, Urakami, A, Zhu, Y   +8 more
core   +1 more source

Osmotic pressure‐induced calcium response states

FEBS Open Bio, EarlyView.
Acute hypotonic stress triggers distinct calcium response patterns in HEK293T cells. These signals originate from the endoplasmic reticulum via RyR2 and propagate to neighboring cells through gap junctions. This result highlights a novel calcium‐dependent mechanism underlying the intracellular and intercellular response to osmotic pressure.
Zidan Gao, Keiji Naruse, Masatoshi Morimatsu   +2 more
wiley   +1 more source

Adenine-induced animal model of chronic kidney disease: current applications and future perspectives

Renal Failure
Chronic kidney disease (CKD) with high morbidity and mortality all over the world is characterized by decreased kidney function, a condition which can result from numerous risk factors, including diabetes, hypertension and obesity.
Qiao Yang, Songya Su, Nan Luo, Gang Cao
doaj   +1 more source

Adenine Phosphoribosyltransferase Deficiency [PDF]

Clinical Journal of the American Society of Nephrology, 2012
Summary Complete adenine phosphoribosyltransferase (APRT) deficiency is a rare inherited metabolic disorder that leads to the formation and hyperexcretion of 2,8-dihydroxyadenine (DHA) into urine. The low solubility of DHA results in precipitation of this compound and the formation of urinary crystals and stones.
Guillaume Bollée, Michel Daudon, Albert Bensman, Irène Ceballos-Picot, Jérôme Harambat, Bertrand Knebelmann   +5 more
openaire   +3 more sources

Physisorption of Nucleobases on Graphene [PDF]

, 2007
We report the results of our first-principles investigation on the interaction of the nucleobases adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U) with graphene, carried out within the density functional theory framework, with ...
C. Klein, F. London, J. D. Watson, N. Nakashima, Rajeev Ahuja, Ralph H. Scheicher, Ravindra Pandey, S. Gowtham, Shashi P. Karna   +8 more
core   +3 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

The Cell Protective Effect of Adenine on Hypoxia–Reoxygenation Injury through PPAR Delta Activation

Life, 2021
Ischemia followed by blood supply reperfusion in cardiomyocytes leads to an overproduction of free radicals and a rapid decrease of adenosine triphosphate concentration.
Jyh-Gang Leu, Chien-Mei Wang, Chao-Yi Chen, Yi-Feng Yang, Chin-Yu Shih, Jiun-Tsai Lin, Han-Min Chen, Yao-Jen Liang   +7 more
doaj   +1 more source

Polarographic Behaviour of Adenine [PDF]

Nature, 1946
WORK in this laboratory on differences in mechanism between normal and malignant cells has shown the great need for improved methods of analysis and characterization of nucleic acids. Investigations which I began before the War indicated to me the value of the polarograph as an analytical tool in the study of inorganic cell constituents, and there was ...
openaire   +3 more sources