Results 71 to 80 of about 487,247 (373)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Galangin attenuates adenine-induced chronic renal failure by inhibiting transforming growth factor beta (TGF-β) expression [PDF]

Journal of Nephropathology
Introduction: Galangin (3,5,7 tri-hydroxy flavone), naturally active flavonoid is derived from the rhizomes of Alpinia officinarum is proven to be effective antioxidant, anti-inflammatory, anti-cancer.
Deepthi Rayilla, Ganta Suhasin
doaj   +1 more source

Hydro-chemical study of the evolution of interstellar pre-biotic molecules during the collapse of molecular clouds

, 2012
One of the stumbling blocks for studying the evolution of interstellar molecules is the lack of adequate knowledge of the rate co-efficients of various reactions which take place in the Interstellar medium and molecular clouds.
Ankan Das, Boogert, Chakrabarti, Chakrabarti, Chakrabarti, Cuppen, Das, Fuente, Gibb, Guelin, Ioppolo, Kuan, Liton Majumdar, Sandip K. Chakrabarti, Snyder, Sonali Chakrabarti, Woon   +16 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Immobilization and 3D Hot-Junction Formation of Gold Nanoparticles on Two-Dimensional Silicate Nanoplatelets as Substrates for High-Efficiency Surface-Enhanced Raman Scattering Detection

Nanomaterials, 2019
We synthesize a high-efficiency substrate for surface-enhanced Raman scattering (SERS) measurements, which is composed of gold nanoparticles (AuNPs) on two-dimensional silicate nanoplatelets acting as an inorganic stabilizer, via the in-situ reduction of
Yen-Chen Lee, Chih-Wei Chiu
doaj   +1 more source

Process study of ceramic membrane-coupled mixed-cell fermentation for the production of adenine

Frontiers in Bioengineering and Biotechnology, 2022
In order to solve the problems of high complexity, many by-products, high pollution and difficult extraction of the existing adenine production process, in this study, ceramic membrane-coupled mixed cell fermentation was used to produce adenine while ...
Pengjie Sun, Pengjie Sun, Changgeng Li, Changgeng Li, Yu Gong, Yu Gong, Jinduo Wang, Jinduo Wang, Qingyang Xu, Qingyang Xu   +9 more
doaj   +1 more source

Polarographic Behaviour of Adenine [PDF]

Nature, 1946
WORK in this laboratory on differences in mechanism between normal and malignant cells has shown the great need for improved methods of analysis and characterization of nucleic acids. Investigations which I began before the War indicated to me the value of the polarograph as an analytical tool in the study of inorganic cell constituents, and there was ...
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii

IUCrJ, 2017
S-Adenosyl-l-homocysteine hydrolase (SAHase) from the symbiotic bacterium Bradyrhizobium elkanii (BeSAHase) was crystallized in four ligand complexes with (i) mixed adenosine (Ado) and cordycepin (Cord; 3′-deoxyadenosine), (ii) adenine (Ade), (iii) Ado ...
Tomasz Manszewski, Kamil Szpotkowski, Mariusz Jaskolski   +2 more
doaj   +1 more source

Adenine base editing in an adult mouse model of tyrosinemia

Nature Biomedical Engineering, 2019
In contrast to traditional CRISPR–Cas9 homology-directed repair, base editing can correct point mutations without supplying a DNA-repair template. Here we show in a mouse model of tyrosinaemia that hydrodynamic tail-vein injection of plasmid DNA encoding
Chun‐Qing Song, Tingting Jiang, M. Richter, Luke H. Rhym, Luke W. Koblan, M. Zafra, Emma M Schatoff, Jordan L. Doman, Yueying Cao, L. Dow, L. Zhu, Daniel G. Anderson, David R. Liu, Hao Yin, Wen Xue   +14 more
semanticscholar   +1 more source