Results 121 to 130 of about 34,085 (286)

Library‐Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity

Advanced Science
The current‐generation adenine base editor (ABE) ABE8e, which has evolved from the prokaryotic evolution system, exhibits high efficiency in mediating A‐to‐G conversion and is presumed to be promising for gene therapy.
Shenlin Hsiao, Shuanghong Chen, Yanhong Jiang, Qiudao Wang, Yang Yang, Yongrong Lai, Tao Zhong, Jiaoyang Liao, Yuxuan Wu   +8 more
doaj   +1 more source

Characterization of Substitution Mutations of eIF4G Gene Generated through Adenine Base Editors in Rice [PDF]

, 2021
Yaiphabi Kumam, C Rajadurai, K. K. Kumar, S. Varanavasiappan, M Raveendran, S. Manonmani, Chandrasekhar Gopalakrishnan, L. Arul, E. Kokiladevi, D. Sudhakar   +9 more
openalex   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Non-random structures in universal compression and the Fermi paradox

, 2016
We study the hypothesis of information panspermia assigned recently among possible solutions of the Fermi paradox ("where are the aliens?"). It suggests that the expenses of alien signaling can be significantly reduced, if their messages contain ...
Allahverdyan, A. E., Gurzadyan, A. V.
core   +1 more source

A Review: Some biological effects of high LET radiations [PDF]

, 1972
There are qualitative and quantitative differences in the biological damage observed after exposure to high LET radiation as compared to that caused by low LET radiations. This review is concerned with these differences, which are ultimately reflected at
Wiley, A., Jr.
core   +1 more source

Secondary structure formation of homopolymeric single-stranded nucleic acids including force and loop entropy: implications for DNA hybridization

, 2011
Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a loop of length m,
Einert, Thomas R., Netz, Roland R., Orland, Henri   +2 more
core   +1 more source

Machine Learning Prediction of DNA Charge Transport

, 2018
First principle calculations of charge transfer in DNA molecules are computationally expensive given that charge carriers migrate in interaction with intra- and inter-molecular atomic motion. Screening sequences, e.g.
Korol, Roman, Segal, Dvira
core   +2 more sources

Technobiological Pathways for High‐CO₂ Capture Using Micro‐/Macroalgae: Genetic Engineering, Process Automation, and Value‐Added Bioproducts

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Greenhouse gas (GHG) emissions have emerged as one of the most critical drivers of climate change; this is primarily due to high concentrations and long atmospheric life of carbon dioxide (CO2). For a significant amount of time, various biological processes such as microalgal cultivation, cyanobacterial systems, photosynthetic microorganisms ...
Sadhana Semwal, Harish Chandra Joshi
wiley   +1 more source

Coiled-coil heterodimer-mediated split base editing systems enable flexible and robust nucleotide substitutions

Nature Communications
Base editors (BEs) enable precise base substitutions, but their size exceeds the packaging capacity of adeno-associated virus (AAV), impeding in vivo applications.
Shuangshuang Mu, Qianru Li, Menglong Chen, Ziqi Li, Yuke Ma, Yuqi Li, Yiran Song, Shuangying Hou, Yuting Ding, Jialu Ju, Yue Lin, Jian Zhang, Yuanxi Yang, Xue Ren, Nan Li, Qin Jin, Liangxue Lai, Kepin Wang, Hui Shi   +18 more
doaj   +1 more source

Optimizing Pichia Pastoris Cell‐Free Protein Synthesis to Improve Economics

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cell‐free protein synthesis (CFPS) is a powerful and versatile platform that supports a wide range of applications, from fundamental studies of the genetic code to scalable and rapid protein production. The recently developed Pichia pastoris CFPS combines advantages of both prokaryotic and eukaryotic systems, including a rapid growth rate ...
Rui Wu, Igor Koop, Gavin Murugan, Thagshanen Thillairajah, Karen M. Polizzi   +4 more
wiley   +1 more source