Results 141 to 150 of about 34,085 (286)

LNP‐mediated in vivo base editing corrects Agxt to cure primary hyperoxaluria type 1

Clinical and Translational Medicine
Objective Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder caused by AGXT mutations, leading to hepatic oxalate overproduction, nephrolithiasis, and progressive renal failure. This study aims to evaluate the therapeutic potential
Dexin Zhang, Rui Zheng, Zhoutong Chen, Xi Chen, Lei Yang, Yanan Huo, Yining Zhao, Jiaxin Huang, Dan Zhang, Shuming Yin, Dali Li, Hongquan Geng   +11 more
doaj   +1 more source

Regulation of reactivated elongation in lysed cell models of teleost retinal cones by cAMP and calcium. [PDF]

, 1986
Teleost retinal cones elongate in the dark and contract in the light. In isolated retinas of the green sunfish Lepomis cyanellus, cone myoids undergo microtubule-dependent elongation from 5 to 45 micron. We have previously shown that cone contraction can
Ackland, N, BURNSIDE, Beth, Gilson, C
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

On ultraviolet light and the origin of ribosomes [PDF]

Function of UV light in evolution of contemporary ...
Sagan, C., Shapshak, P.
core   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Structural and functional insights into internal domain replacement in SpCas9 for protein engineering

Scientific Reports
The CRISPR-Cas9 system has emerged as a powerful tool for precise genome editing, with ongoing research focused on enhancing its reliability and expanding its versatility. One effective strategy involves the integration of foreign functional domains into
Seonhong Kim, Hyuk Won, Jungnam Bae, Jeesoo Kim, Jinhyuk Choi, Halimriadi Richar, Yang-Gyun Kim, Hee-Jung Choi   +7 more
doaj   +1 more source

Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway

, 2022
Yudong Yang, Chi Zhang, Yixuan Song, Yawen Li, Pingping Li, Min Huang, Fei‐Long Meng, Mingliang Zhang   +7 more
openalex   +1 more source

Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors [PDF]

, 2022
Jessie R. Davis, Xiao Wang, Isaac P. Witte, Tony P. Huang, Jonathan M. Levy, Aditya Raguram, Samagya Banskota, Nabil G. Seidah, Kiran Musunuru, David R. Liu   +9 more
openalex   +1 more source

Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. [PDF]

Sci Rep, 2023
Nandy K, Babu D, Rani S, Joshi G, Ijee S, George A, Palani D, Premkumar C, Rajesh P, Vijayanand S, David E, Murugesan M, Velayudhan SR.   +12 more
europepmc   +1 more source

High performance TadA-8e derived cytosine and dual base editors with undetectable off-target effects in plants

Nature Communications
Cytosine base editors (CBEs) and adenine base editors (ABEs) enable precise C-to-T and A-to-G edits. Recently, ABE8e, derived from TadA-8e, enhances A-to-G edits in mammalian cells and plants.
Tingting Fan, Yanhao Cheng, Yuechao Wu, Shishi Liu, Xu Tang, Yao He, Shanyue Liao, Xuelian Zheng, Tao Zhang, Yiping Qi, Yong Zhang   +10 more
doaj   +1 more source