Results 151 to 160 of about 19,262 (234)

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

Directed-evolution mutations enhance DNA-binding affinity and protein stability of the adenine base editor ABE8e. [PDF]

Cell Mol Life Sci
Zhu H, Wang L, Wang Y, Jiang X, Qin Q, Song M, Huang Q.   +6 more
europepmc   +1 more source

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope. [PDF]

Nat Commun, 2020
Jiang T, Henderson JM, Coote K, Cheng Y, Valley HC, Zhang XO, Wang Q, Rhym LH, Cao Y, Newby GA, Bihler H, Mense M, Weng Z, Anderson DG, McCaffrey AP, Liu DR, Xue W.   +16 more
europepmc   +1 more source

The DIKW of Transcriptomics in Ecotoxicology: Extracting Information, Knowledge, and Wisdom From Big Data

Environmental Toxicology and Chemistry, EarlyView.
Jessica A. Head, Jessica D. Ewald, Niladri Basu   +2 more
wiley   +1 more source

Analysis of Notch1 and Notch3 Signaling Pathway Components in Benign Prostatic Hyperplasia and Prostate Cancer Patients

Journal of Clinical Laboratory Analysis, EarlyView.
This study evaluates the association between Notch1 and Notch3 genetic variations and serum protein levels in patients with benign prostatic hyperplasia and prostate cancer. While genetic variations showed no significant link to disease risk, serum protein levels were significantly lower in prostate cancer and metastatic groups compared to healthy ...
Emine Yagci, Cansu Ozbayer, Ata Ozen, Gamze Zengin, Hulyam Kurt   +4 more
wiley   +1 more source

Adenine base editor-based correction of the cardiac pathogenic Lmna c.1621C > T mutation in murine hearts. [PDF]

J Cell Mol Med
Yang L, Liu Z, Sun J, Chen Z, Gao F, Guo Y.   +5 more
europepmc   +1 more source

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source