Results 221 to 230 of about 19,262 (234)

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing

Nature Biotechnology, 2020
Jae Joung, Julian Grunewald, Sowmya Iyer   +2 more
exaly  

COMBINATORIAL ADENINE AND CYTOSINE DNA BASE EDITORS

2021
JOUNG J KEITH, ZHOU RONGHAO, GRUNEWALD JULIAN   +2 more
openaire   +1 more source

Engineered Nme2Cas9 Adenine Base Editors to Treat Rett Syndrome

Rett syndrome (RTT) is a severe X-linked progressive neurodevelopmental disorder that primarily affects females in early childhood. Although the FDA has approved the first drug treatment for RTT, no curative therapy is currently available. Precision genome editing technologies—particularly CRISPR-based adenine base editing (ABE)—offer a promising ...
openaire   +1 more source

Hypercompact adenine base editors based on a Cas12f variant guided by engineered RNA

Nature Chemical Biology, 2022
Do Yon Kim, Yuhee Chung, Yujin Lee, Dongmin Jeong, Kwang-Hyun Park, Hyun Jung Chin, Jeong Mi Lee, Seyeon Park, Sumin Ko, Jeong-Heon Ko, Yong-Sam Kim   +10 more
openaire   +1 more source

Adenine base editing as a promising therapy for cardiovascular diseases

Global Translational Medicine, 2023
Yuxuan Guo
exaly  

BEON: A Functional Fluorescence Reporter for Quantification and Enrichment of Adenine Base-Editing Activity

Molecular Therapy, 2020
Renzhi Han, Peipei Wang, Yandi Gao
exaly  

WS05.06Design of an adenine base editor for temporospatial control of editing

Journal of Cystic Fibrosis
I. Zollo, L. Santos, J. Alves, A.S. Coroadinha, P.T. Harrison, C.M. Farinha   +5 more
openaire   +1 more source

PROGRAMMABLE ADENINE BASE EDITOR AND USES THEREOF

2023
openaire   +1 more source

CONTEXT-SPECIFIC ADENINE BASE EDITORS AND USES THEREOF

2023
LIU DAVID, ZHAO KEVIN
openaire   +1 more source

Correcting a patient-specific Rhodopsin mutation with adenine base editor in a mouse model

Molecular Therapy
Feng Gu
exaly