Results 251 to 257 of about 19,445 (257)

Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease

Cell Stem Cell, 2021
Yeseul Kim, Sung-Ah Hong, Jihyeon Yu
exaly  

Engineered Nme2Cas9 Adenine Base Editors to Treat Rett Syndrome

Rett syndrome (RTT) is a severe X-linked progressive neurodevelopmental disorder that primarily affects females in early childhood. Although the FDA has approved the first drug treatment for RTT, no curative therapy is currently available. Precision genome editing technologies—particularly CRISPR-based adenine base editing (ABE)—offer a promising ...
openaire   +1 more source

Generation of a high-efficiency adenine base editor with TadA8e for developing wheat dinitroaniline-resistant germplasm

Crop Journal, 2022
Jihu Li, Shujuan Zhang, Changle Ma
exaly  

WS05.06Design of an adenine base editor for temporospatial control of editing

Journal of Cystic Fibrosis
I. Zollo, L. Santos, J. Alves, A.S. Coroadinha, P.T. Harrison, C.M. Farinha   +5 more
openaire   +1 more source

Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-to-K base editing in rice plants

ABIOTECH
Shaoya Li, Jingying Li, Yubing He
exaly  

Biophysical origin of adenine base editors’ improved editing efficiency

Biophysical Journal
Pablo R. Arantes, Souvik Sinha, Xiaoyu Chen, Aakash Saha, Amun C. Patel, Matthew Sample, Lukasz Nierzwicki, Audrone Lapinaite, Giulia Palermo   +8 more
openaire   +1 more source

Adenine base editor‐based correction of the cardiac pathogenic Lmna c.1621C > T mutation in murine hearts

Journal of Cellular and Molecular Medicine
Luzi Yang, Yuxuan Guo
exaly