Results 71 to 80 of about 772,486 (361)
Nitroalkenes Confer Acute Cardioprotection via Adenine Nucleotide Translocase 1*
Journal of Biological Chemistry, 2011 Background: Nitroalkenes are cardioprotective. We investigated the role of ANT1 in this process. Results: Nitro-linoleate modifies Cys57 on ANT1. Knockdown of ANT1 inhibits cytoprotection by nitro-linoleate.
S. Nadtochiy +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Scientific Reports, 2021 All medically important unicellular protozoans cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation.
Eva Doleželová +6 more
doaj +1 more source
Determination of total potentially available nucleosides in bovine milk [PDF]
, 2010 Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D. +2 more
core +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
PLoS ONE, 2013 Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent. Recombinant human Apo2L/TRAIL has been under clinical trials, whereas various kinds of malignant tumors have resistance to Apo2L ...
Masakatsu Oishi +5 more
doaj +1 more source
Influence of a fluorobenzene nucleobase analogue on the conformational flexibility of RNA studied by molecular dynamics simulations [PDF]
, 2006 Chemically modified bases are frequently used to stabilize nucleic acids, to study the driving forces for nucleic acid structure formation and to tune DNA and RNA hybridization conditions.
Engels, Joachim W. (Prof. Dr.) +1 more
core
Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF [PDF]
, 2019 Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself.
Casadesús Pursals, Josep +4 more
core +1 more source
Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
core +2 more sources
Antagonism of Morphine Analgesia by Adenine, Adenosine, and Adenine Nucleotides
Experimental Biology and Medicine, 1973 SummaryAntagonism of the antinociceptive action of morphine in mice by prior parenteral administration of cAMP has been confirmed using two additional analgesic testing procedures, the hot-plate test and the stretching test. The analgesia-antagonistic property, however, is not specific for cAMP because it also occurred after pretreatment with compounds
D R, Gourley, S K, Beckner
openaire +2 more sources