Results 1 to 10 of about 60,520 (158)

Hidden Pool of Cardiac Adenine Nucleotides That Controls Adenosine Production [PDF]

Pharmaceuticals, 2023
Myocardial ischemic adenosine production decreases in subsequent events that may blunt its protective functions. To test the relation between total or mitochondrial cardiac adenine nucleotide pool (TAN) on the energy status with adenosine production ...
Magdalena A. Zabielska-Kaczorowska, Alicja Braczko, Iwona Pelikant-Malecka, Ewa M. Slominska, Ryszard T. Smolenski   +4 more
doaj   +2 more sources

Editorial: Adenine nucleotides in immunity and inflammation [PDF]

Frontiers in Immunology
Christa E. Müller, Santina Bruzzone, Andreas H. Guse   +2 more
doaj   +5 more sources

An Intermediary Role of Adenine Nucleotides on Free Fatty Acids-Induced Hyperglycemia in Obese Mice [PDF]

Frontiers in Endocrinology, 2019
Increased plasma free fatty acids (FFA) level plays a central role in the development of type 2 diabetes. Our previous studies have shown that plasma 5′-adenosine monophosphate (5′-AMP) elevates and acts as a potential upstream regulator of hyperglycemia
Xiao Yang, Yang Zhao, Qi Sun, Yunxia Yang, Yan Gao, Wenhao Ge, Junhao Liu, Xi Xu, Jianfa Zhang   +8 more
doaj   +2 more sources

Advancements in Adenine Nucleotides Extraction and Quantification from a Single Drop of Human Blood [PDF]

Molecules
Adenine nucleotides (ANs)—adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), and adenosine 5′-monophosphate (AMP)—are essential for energy transfer and the supply of countless processes within cellular metabolism.
Ivana Popović, Lucija Dončević, Renata Biba, Karla Košpić, Maja Barbalić, Mija Marinković, Mario Cindrić   +6 more
doaj   +2 more sources

Kinetic analysis of catalytic activity of G-quadruplex/hemin DNAzyme with flanking adenine nucleotides [PDF]

Scientific Reports
G-quadruplex/hemin DNAzymes are promising nucleic acid catalysts due to their versatility and ease of use in biosensing applications. Their peroxidase-like catalytic activity can be enhanced through various strategies, including modifications to flanking
Anuttara Udomprasert, Sutida Chimasungkanun, Thaned Kangsamaksin   +2 more
doaj   +2 more sources

Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger [PDF]

Nature Communications
The ClC-3 chloride/proton exchanger is both physiologically and pathologically critical, as it is potentiated by ATP to detect metabolic energy level and point mutations in ClC-3 lead to severe neurodegenerative diseases in human.
Yangzhuoqun Wan, Shuangshuang Guo, Wenxuan Zhen, Lizhen Xu, Xiaoying Chen, Fangyue Liu, Yi Shen, Shuangshuang Liu, Lidan Hu, Xinyan Wang, Fengcan Ye, Qinrui Wang, Han Wen, Fan Yang   +13 more
doaj   +2 more sources

Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. [PDF]

PLoS ONE, 2016
RationaleDecreased alkaline phosphatase activity after infant cardiac surgery is associated with increased post-operative cardiovascular support requirements.
Jesse A Davidson, Tracy Urban, Suhong Tong, Mark Twite, Alan Woodruff, Paul E Wischmeyer, Jelena Klawitter   +6 more
doaj   +2 more sources

Simultaneous Detection and Quantification of Adenine Nucleotides in Mammalian Cultured Cells by HPLC [PDF]

ACS Omega
Beatriz Kopel, Fernanda Manso Prado, Sofia Lígia Guimarães-Ramos, Rafael Dias de Moura, Paolo Di Mascio, Nícolas Carlos Hoch, Marisa Helena Gennari de Medeiros, Nadja Cristhina de Souza-Pinto   +7 more
doaj   +2 more sources

CoCl₂-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors

Biomedicines, 2022
Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative ...
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski   +6 more
doaj   +1 more source

A liquid chromatography-tandem mass spectrometry based method for the quantification of adenosine nucleotides and NAD precursors and products in various biological samples

Frontiers in Immunology, 2023
Adenine nucleotides (AN) are ubiquitous metabolites that regulate cellular energy metabolism and modulate cell communication and inflammation. To understand how disturbances in AN balance arise and affect cellular function, robust quantification ...
Johanna Hiefner, Johann Rische, Madeleine J. Bunders, Madeleine J. Bunders, Madeleine J. Bunders, Anna Worthmann   +5 more
doaj   +1 more source