Results 1 to 10 of about 686,474 (304)

Hidden Pool of Cardiac Adenine Nucleotides That Controls Adenosine Production [PDF]

Pharmaceuticals, 2023
Myocardial ischemic adenosine production decreases in subsequent events that may blunt its protective functions. To test the relation between total or mitochondrial cardiac adenine nucleotide pool (TAN) on the energy status with adenosine production ...
Magdalena A. Zabielska-Kaczorowska, Alicja Braczko, Iwona Pelikant-Malecka, Ewa M. Slominska, Ryszard T. Smolenski   +4 more
doaj   +2 more sources

Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides. [PDF]

JCI Insight, 2019
Although oxidative stress plays central roles in postischemic renal injury, region-specific alterations in energy and redox metabolism caused by short-duration ischemia remain unknown.
Fujii K, Kubo A, Miyashita K, Sato M, Hagiwara A, Inoue H, Ryuzaki M, Tamaki M, Hishiki T, Hayakawa N, Kabe Y, Itoh H, Suematsu M.   +12 more
europepmc   +2 more sources

Structural basis of AMPK regulation by adenine nucleotides and glycogen. [PDF]

Cell Res, 2015
AMP-activated protein kinase (AMPK) is a central cellular energy sensor and regulator of energy homeostasis, and a promising drug target for the treatment of diabetes, obesity, and cancer.
Li X, Wang L, Zhou XE, Ke J, de Waal PW, Gu X, Tan MH, Wang D, Wu D, Xu HE, Melcher K.   +10 more
europepmc   +2 more sources

An Intermediary Role of Adenine Nucleotides on Free Fatty Acids-Induced Hyperglycemia in Obese Mice [PDF]

Frontiers in Endocrinology, 2019
Increased plasma free fatty acids (FFA) level plays a central role in the development of type 2 diabetes. Our previous studies have shown that plasma 5′-adenosine monophosphate (5′-AMP) elevates and acts as a potential upstream regulator of hyperglycemia
Xiao Yang, Yang Zhao, Qi Sun, Yunxia Yang, Yan Gao, Wenhao Ge, Junhao Liu, Xi Xu, Jianfa Zhang   +8 more
doaj   +2 more sources

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart. [PDF]

PLoS ONE, 2013
Reduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy state.
Kiterie M E Faller, Debra J Medway, Dunja Aksentijevic, Liam Sebag-Montefiore, Jürgen E Schneider, Craig A Lygate, Stefan Neubauer   +6 more
doaj   +9 more sources

BLOOD LEVELS OF ADENINE NUCLEOTIDES 1 [PDF]

Journal of Clinical Investigation, 1951
Recently a rapid reliable method was developed by one of us (13) for measuring total adenine, adenylic acid (AMP), adenosine diphosphate (ADP) and adenosine triphosphate (ATP). We have applied this method to the study of blood since it is the only human tissue which can be conveniently studied.
Harry G. Albaum, Theodore Cayle, Arthur M. Shapiro   +2 more
openalex   +4 more sources

Advancements in Adenine Nucleotides Extraction and Quantification from a Single Drop of Human Blood [PDF]

Molecules
Adenine nucleotides (ANs)—adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), and adenosine 5′-monophosphate (AMP)—are essential for energy transfer and the supply of countless processes within cellular metabolism.
Ivana Popović, Lucija Dončević, Renata Biba, Karla Košpić, Maja Barbalić, Mija Marinković, Mario Cindrić   +6 more
doaj   +2 more sources

Differential sensitivity and specificity of Aedes aegypti and Anopheles gambiae to adenine nucleotide phagostimulants—an all-or-none response? [PDF]

Parasites & Vectors
Background The decision to imbibe a blood meal is predominantly dependent on the sensitivity and specificity of haematophagous arthropods to blood-derived adenine nucleotides, in particular adenosine triphosphate (ATP).
Matthew Lukenge, Rickard Ignell, Sharon Rose Hill   +2 more
doaj   +2 more sources

Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger [PDF]

Nature Communications
The ClC-3 chloride/proton exchanger is both physiologically and pathologically critical, as it is potentiated by ATP to detect metabolic energy level and point mutations in ClC-3 lead to severe neurodegenerative diseases in human.
Yangzhuoqun Wan, Shuangshuang Guo, Wenxuan Zhen, Lizhen Xu, Xiaoying Chen, Fangyue Liu, Yi Shen, Shuangshuang Liu, Lidan Hu, Xinyan Wang, Fengcan Ye, Qinrui Wang, Han Wen, Fan Yang   +13 more
doaj   +2 more sources

Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. [PDF]

PLoS ONE, 2016
RATIONALE:Decreased alkaline phosphatase activity after infant cardiac surgery is associated with increased post-operative cardiovascular support requirements. In adults undergoing coronary artery bypass grafting, alkaline phosphatase infusion may reduce
Jesse A Davidson, Tracy Urban, Suhong Tong, Mark Twite, Alan Woodruff, Paul E Wischmeyer, Jelena Klawitter   +6 more
doaj   +2 more sources