Results 1 to 10 of about 114,992 (358)
A flexible model-based framework for robust estimation of mutational signatures [PDF]
arXiv, 2022 Somatic mutations in cancer can be viewed as a mixture distribution of several mutational signatures, which can be inferred using non-negative matrix factorization (NMF). Mutational signatures have previously been parametrized using either simple mono-nucleotide interaction models or general tri-nucleotide interaction models. We describe a flexible and
arxiv
Clinics, 2011 OBJECTIVES: Aerobic exercise training prevents cardiovascular risks. Regular exercise promotes functional and structural adaptations that are associated with several cardiovascular benefits. The aim of this study is to investigate the effects of swimming
Fernanda R. Roque +7 more
doaj +1 more source
BiomedicinesAdenine nucleotides play a critical role in maintaining essential functions of red blood cells (RBCs), including energy metabolism, redox status, shape fluctuations and RBC-dependent endothelial and microvascular functions.
Marzena Romanowska-Kocejko +9 more
doaj +1 more source
Characterizing large scale base composition structures of genomes [PDF]
arXiv, 2004 Intermittent density fluctuations of nucleotide molecules (adenine, guanine, cytosine and thymine) along DNA sequences are studied in the framework of a hierarchical structure (HS) model originally proposed for the study of fully developed turbulence [She and Leque, Phys. Rev. Lett. 72}, 336 (1994)].
arxiv
STAR Protocols, 2020 Summary: Nucleoside-containing metabolites such as the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD+ and NADH), 3′-desphospho-coenzyme A (dpCoA), and flavin adenine dinucleotide (FAD) can be incorporated as RNA 5′ end caps by ...
Irina O. Vvedenskaya, Bryce E. Nickels
doaj
AMP-activated protein kinase – not just an energy sensor [version 1; referees: 3 approved]
F1000Research, 2017 Orthologues of AMP-activated protein kinase (AMPK) occur in essentially all eukaryotes as heterotrimeric complexes comprising catalytic α subunits and regulatory β and γ subunits.
David Grahame Hardie, Sheng-Cai Lin
doaj +1 more source
Two-dimensional chemical mapping for non-coding RNAs [PDF]
arXiv, 2011 Non-coding RNA molecules fold into precise base pairing patterns to carry out critical roles in genetic regulation and protein synthesis. We show here that coupling systematic mutagenesis with high-throughput SHAPE chemical mapping enables accurate base pair inference of domains from ribosomal RNA, ribozymes, and riboswitches.
arxiv
Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir
The Innovation, 2021 Summary: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into an unprecedented global pandemic. Nucleoside analogs, such as Remdesivir and Favipiravir, can serve as the first-line broad-spectrum antiviral drugs ...
Qi Peng +7 more
doaj
Chirality in a quaternionic representation of the genetic code [PDF]
arXiv, 2015 A quaternionic representation of the genetic code, previously reported by the authors, is updated in order to incorporate chirality of nucleotide bases and amino acids. The original representation assigns to each nucleotide base a prime integer quaternion of norm 7 and involves a function that associates with each codon, represented by three of these ...
arxiv
Journal of Biological Engineering, 2017 Background In the yeast Saccharomyces cerevisiae, as in every eukaryotic organism, the mRNA 5′-untranslated region (UTR) is important for translation initiation. However, the patterns and mechanisms that determine the efficiency with which ribozomes bind
Jing Li +3 more
doaj +1 more source