Hidden Pool of Cardiac Adenine Nucleotides That Controls Adenosine Production [PDF]
Pharmaceuticals, 2023 Myocardial ischemic adenosine production decreases in subsequent events that may blunt its protective functions. To test the relation between total or mitochondrial cardiac adenine nucleotide pool (TAN) on the energy status with adenosine production ...
Magdalena A. Zabielska-Kaczorowska +4 more
doaj +2 more sources
An Intermediary Role of Adenine Nucleotides on Free Fatty Acids-Induced Hyperglycemia in Obese Mice [PDF]
Frontiers in Endocrinology, 2019 Increased plasma free fatty acids (FFA) level plays a central role in the development of type 2 diabetes. Our previous studies have shown that plasma 5′-adenosine monophosphate (5′-AMP) elevates and acts as a potential upstream regulator of hyperglycemia
Xiao Yang +8 more
doaj +2 more sources
Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart. [PDF]
PLoS ONE, 2013 BackgroundReduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy ...
Kiterie M E Faller +6 more
doaj +13 more sources
Advancements in Adenine Nucleotides Extraction and Quantification from a Single Drop of Human Blood [PDF]
MoleculesAdenine nucleotides (ANs)—adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), and adenosine 5′-monophosphate (AMP)—are essential for energy transfer and the supply of countless processes within cellular metabolism.
Ivana Popović +6 more
doaj +2 more sources
Kinetic analysis of catalytic activity of G-quadruplex/hemin DNAzyme with flanking adenine nucleotides [PDF]
Scientific ReportsG-quadruplex/hemin DNAzymes are promising nucleic acid catalysts due to their versatility and ease of use in biosensing applications. Their peroxidase-like catalytic activity can be enhanced through various strategies, including modifications to flanking
Anuttara Udomprasert +2 more
doaj +2 more sources
Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger [PDF]
Nature CommunicationsThe ClC-3 chloride/proton exchanger is both physiologically and pathologically critical, as it is potentiated by ATP to detect metabolic energy level and point mutations in ClC-3 lead to severe neurodegenerative diseases in human.
Yangzhuoqun Wan +13 more
doaj +2 more sources
Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. [PDF]
PLoS ONE, 2016 RationaleDecreased alkaline phosphatase activity after infant cardiac surgery is associated with increased post-operative cardiovascular support requirements.
Jesse A Davidson +6 more
doaj +2 more sources
Editorial: Adenine nucleotides in immunity and inflammation [PDF]
Frontiers in ImmunologyChrista E. Müller +2 more
doaj +2 more sources
Biomedicines, 2022 Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative ...
Barbara Kutryb-Zajac +6 more
doaj +1 more source
Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants [PDF]
Current Protocols in Plant Biology, 2020 AbstractAs the principal co‐factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism. However, given their rapid and reversible conversion as well as their relatively low concentration ranges, it is difficult to measure these ...
Zhang, Youjun +4 more
openaire +4 more sources