Results 61 to 70 of about 6,350 (165)

Advancing antihypertensive drug development

British Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse [PDF]

, 2013
Closure of the neural tube during embryogenesis is a crucial step in development of the central nervous system. Failure of this process results in neural tube defects, including spina bifida and anencephaly, which are among the most common birth defects ...
Copp, AJ, De Castro, SC, Greene, ND, Leung, KY, Savery, D   +4 more
core   +1 more source

Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010

Microbial Biotechnology, Volume 18, Issue 7, July 2025.
In this study, we examined the highly conserved upp gene in bifidobacteria, which encodes uracil phosphoribosyltransferase and plays a role in the pyrimidine salvage pathway. Specifically, we explore its evolutionary trajectory in bifidobacteria, shedding light on its role in microbial competition in the human gut.
Giulia Longhi, Silvia Petraro, Christian Milani, Chiara Tarracchini, Chiara Argentini, Laura Maria Vergna, Gabriele Andrea Lugli, Leonardo Mancabelli, Ciaran Lee, Francesca Turroni, Douwe van Sinderen, Marco Ventura   +11 more
wiley   +1 more source

Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]

, 2016
Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina, Pertusati, Fabrizio, Serpi, Michaela   +2 more
core   +1 more source

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD

Biomolecules, 2021
It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is transformed into the NAD analog vacor
Lars Jansen Sverkeli, Faisal Hayat, Marie E. Migaud, Mathias Ziegler   +3 more
doaj   +1 more source

Phenotype and Genotype Characterization of Adenine Phosphoribosyltransferase Deficiency [PDF]

Journal of the American Society of Nephrology, 2010
Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder causing 2,8-dihydroxyadenine stones and renal failure secondary to intratubular crystalline precipitation. Little is known regarding the clinical presentation of APRT deficiency, especially in the white population. We retrospectively reviewed all 53 cases of APRT
Albert Bensman, Patrice Deteix, Lucile Boutaud, Guillaume Bollée, Jérôme Harambat, Irène Ceballos-Picot, Michel Daudon, Delphine Guillemot, Cécile Dollinger, Bertrand Knebelmann   +9 more
openaire   +3 more sources

Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders

Cells, 2020
Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine ...
Ali Dakroub, Suzanne A. Nasser, Nour Younis, Humna Bhagani, Yusra Al-Dhaheri, Gianfranco Pintus, Assaad A. Eid, Ahmed F. El-Yazbi, Ali H. Eid   +8 more
doaj   +1 more source

Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]

, 2016
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P., Hofer, Anders, Pavlova, Anna, Ranjbarian, Farahnaz, Vodnala, Munender   +4 more
core   +1 more source

Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells. [PDF]

PLoS ONE, 2014
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensively
Vladimir Tolstikov, Alexander Nikolayev, Sucai Dong, Genshi Zhao, Ming-Shang Kuo   +4 more
doaj   +1 more source

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source