Results 61 to 70 of about 87,339 (215)

Kinetic Studies of Adenine Phosphoribosyltransferase

Journal of Biological Chemistry, 1966
Abstract The mechanism of reaction of adenine phosphoribosyl-transferase from Ehrlich ascites tumor cells was investigated kinetically by initial velocity and product inhibition studies. The data are consistent with a mechanism in which 5-phosphoribosylpyrophosphate reacts with the enzyme to form an intermediate, presumably an enzyme-ribose 5-phosphate
M, Hori, J F, Henderson
openaire   +2 more sources

Mouse Model of Weak Depression Exhibiting Suppressed cAMP Signaling in the Amygdala, Lower Lipid Catabolism in Liver, and Correlated Gut Microbiota

Frontiers in Behavioral Neuroscience, 2022
To establish a mouse model of weak depression, we raised 6-week-old C57BL/6N mice in single (SH) or group housing (GH) conditions for 2 weeks. The SH group showed less social interaction with stranger mice, learning disability in behavioral tests, and ...
Kousuke Shimada, Masakatsu Nohara, Akihito Yasuoka, Akihito Yasuoka, Asuka Kamei, Fumika Shinozaki, Kaori Kondo, Kaori Kondo, Ryo Inoue, Takashi Kondo, Takashi Kondo, Keiko Abe, Keiko Abe   +12 more
doaj   +1 more source

Adenine phosphoribosyltransferase deficiency as a rare cause of renal allograft dysfunction.

J Am Soc Nephrol, 2014
Kaartinen K, Hemmilä U, Salmela K, Räisänen-Sokolowski A, Kouri T, Mäkelä S.   +5 more
europepmc   +2 more sources

Renal stones in two children with two rare etiologies

Saudi Journal of Kidney Diseases and Transplantation, 2018
The incidence of urolithiasis in children has shown an increase in recent years which may be attributed to changing dietary patterns, sedentary lifestyles, and obesity.
Gurinder Kumar, Rami Raad AlAni
doaj   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure

JACC: Basic to Translational Science
Summary: Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD+) levels in human systolic and diastolic HF and in a murine model of HF ...
Yen Chin Koay, PhD, Ren Ping Liu, BS, Bailey McIntosh, BS, Niv Vigder, BS, Serlin Lauren, BS, Angela Yu Bai, BS, Saki Tomita, BS, Desmond Li, PhD, Dylan Harney, PhD, Benjamin Hunter, PhD, Yunwei Zhang, PhD, Jean Yang, PhD, Paul Bannon, MD, PhD, Ashleigh Philp, PhD, Andrew Philp, PhD, David M. Kaye, MD, PhD, Mark Larance, PhD, Sean Lal, MD, PhD, John F. O’Sullivan, MD, PhD   +18 more
doaj   +1 more source

Regulation of yak longissimus lumborum energy metabolism and tenderness by the AMPK/SIRT1 signaling pathways during postmortem storage

PLoS ONE, 2022
AMPK can activate nicotinamide phosphoribosyltransferase (NAMPT), increasing the ratio of oxidized nicotinamide adenine dinucleotide (NAD+)/reduced nicotinamide adenine dinucleotide (NADH) ratio, leading to the activation of the energy receptor SIRT1 ...
Yayuan Yang, Jieyuan Yang, Qunli Yu, Yongfang Gao, Ya Zheng, Ling Han, Xuezhi Ding   +6 more
doaj   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis

Frontiers in Public Health, 2023
ObjectiveAging is associated with decreased nicotinamide adenine dinucleotide (NAD) levels, which in turn cause dysfunctional mitochondria and indirectly affect a myriad of diseases. Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) serves as
Xu Sun, Lide Su, Lide Su, Te Bu, Te Bu, Yang Zhang   +5 more
doaj   +1 more source

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, EarlyView.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source