Results 161 to 170 of about 396,665 (375)
Recent Advances in mRNA Delivery Systems for Cancer Therapy
Advanced Science, EarlyView.This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang +9 more
wiley +1 more source
Genome Biology, 2015 CRISPR-Cas systems have been broadly embraced as effective tools for genome engineering applications, with most studies to date utilizing the Streptococcus pyogenes Cas9.
Ari E. Friedland +15 more
semanticscholar +1 more source
Advanced Science, EarlyView.The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang +5 more
wiley +1 more source
Cleavage of adeno-associated virus DNA with SalI, PstI and HaeII restriction endonucleases [PDF]
, 1976 Luis M. de la Maza, B. J. Carter
openalex +1 more source
Advanced Science, EarlyView.Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun +15 more
wiley +1 more source
AAV vectors accumulate in the pineal gland after injections into the brain or spinal cord
Molecular Therapy: Methods & Clinical Development, 2021 AAV vectors are being used extensively for gene-modifying therapies for neurological disorders. Here, we report the surprising discovery that injections of different AAVs into the brain, spinal cord, or cerebrospinal fluid (CSF) lead to robust ...
Oswald Steward +4 more
doaj
The acquisition of antibodies adeno-associated satellite viruses [PDF]
, 1971 Martha D. Yow +3 more
openalex +1 more source
Intracellular trafficking of adeno-associated virus (AAV) vectors: challenges and future directions
Gene Therapy, 2021 Jalish M. Riyad, T. Weber
semanticscholar +1 more source
Advanced Science, EarlyView.Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch +13 more
wiley +1 more source
A recombinant avian adeno-associated virus as a vector for infectious bursal disease vaccination.
Revista Científica, 2010 Infectious bursal disease is a worldwide distributed immunosuppressive disease of young chickens that need to be controlled by vaccination; it represents one of the main concerns for the poultry industry.
Francisco Perozo +4 more
doaj