Results 201 to 210 of about 116,785 (352)

Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions

Biotechnology Progress, EarlyView.
Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal, Asingsa W. Arachchige, Annabelle J. Zahn, S. Ranil Wickramasinghe, Xianghong Qian, Andrew L. Zydney   +5 more
wiley   +1 more source

Tropism and Retinal Transduction Efficiency of Adeno-Associated Virus Serotypes in Mice. [PDF]

Invest Ophthalmol Vis Sci
Wu W, McRae J, Brown A, Agbaga MP.
europepmc   +1 more source

Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks

Chemistry – A European Journal, EarlyView.
A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan, Ethan J. French, Emerenziana Runco, Chetan B. Dhakan, Jinwu Yan, Hiroshi Nakashima, Michael T. McMahon, Assaf A. Gilad, Christian T. Farrar   +8 more
wiley   +1 more source

Characterization of difficult-to-remove host cell proteins in adeno-associated virus downstream processing. [PDF]

Mol Ther Methods Clin Dev
Leibiger TM, Min L, Lee KH.
europepmc   +1 more source

Probing the Link among Genomic Cargo, Contact Mechanics, and Nanoindentation in Recombinant Adeno-Associated Virus 2

, 2017
Cheng Zeng, Sven Møller-Tank, Aravind Asokan, Bogdan Dragnea   +3 more
openalex   +2 more sources

Glycan Binding Avidity Determines the Systemic Fate of Adeno-Associated Virus Type 9 [PDF]

, 2012
Shen Shen, Kelli D. Bryant, Junjiang Sun, Sarah M. Brown, Andrew N. Troupes, Nagesh Pulicherla, Aravind Asokan   +6 more
openalex   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Methodological validation of a cryo-TEM-based detection method for empty capsid ratio in recombinant adeno-associated virus. [PDF]

Biochem Biophys Rep
Xu L, Chen J, Zhu W, Zhao Y, Zheng F, Du R, Jiang Y, Yang Y, Chen Y, Dong Y, Zhang Z, Tong Y.   +11 more
europepmc   +1 more source

Obstacles and Circumvention Strategies for Hematopoietic Stem Cell Transduction by Recombinant Adeno-associated Virus Vectors

, 2009
Caroline Njeri Maina
openalex   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source