Results 231 to 240 of about 116,785 (352)

Schisantherin A: Remodeling Gut Microbiota to Activate the Gut–Immune–Neural–Adipose Axis for Thermogenesis

iNew Medicine, EarlyView.
ABSTRACT The global obesity epidemic necessitates safe and effective strategies to enhance energy expenditure. Schisantherin A (Sin A), a lignan derived from Schisandra chinensis, has demonstrated metabolic benefits, yet its systemic mechanism remains unclear.
Ling Yin
wiley   +1 more source

Accelerated Adeno Associated Virus Upstream Process Development From High-Throughput Systems to Clinical Scale. [PDF]

Biotechnol Bioeng
Andaluz A, Monteverde B, Vera K, Tse B, Gajic I, Forelich C, Motevalian SP.   +6 more
europepmc   +1 more source

Capture of adeno‐associated viruses from clarified lysate by continuous flow ultracentrifugation: a comparative study of iodixanol and sucrose gradients

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Adeno‐Associated Virus vectors are widely used in gene therapy due to their safety and efficacy. Despite the interest in their therapeutical application, AAV purification remains a significant challenge. Density gradient ultracentrifugation using cesium chloride, sucrose, or iodixanol gradients are common methods for AAV ...
Sabrina Leigheb, Maral Rahimzadeh, Nikolaus Virgolini, Aida Tleuova, Mahbod Mousavian, Astrid Dürauer, Patricia Pereira Aguilar   +6 more
wiley   +1 more source

Adeno-associated virus and hepatocytes: frenemies? [PDF]

Blood Adv
Pierce GF.
europepmc   +1 more source

Noninvasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virus

, 2014
Shuang Wang, Oluyemi Olumolade, Tao Sun, Gesthimani Samiotaki, Elisa E. Konofagou   +4 more
openalex   +1 more source

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen, Yong‐Hong Yu, Yan‐Hua Du, Lin Xu, Xiang‐Ping Meng   +4 more
wiley   +1 more source

Impact of multiplicity of infection and baculovirus co-infection ratio on recombinant adeno-associated virus vector production in insect cells. [PDF]

Front Bioeng Biotechnol
Schrama M, de Jong LA, Kint S, Puri P, Hoeksema F, Pijlman GP, van Oers MM, Wijffels RH, Martens DE.   +8 more
europepmc   +1 more source

Adeno-Associated Virus Inverted Terminal Repeats Improve Neuronal Transgene Expression Mediated by Baculoviral Vectors in Rat Brain

, 2005
Chaoyang Wang, Shu Wang
openalex   +2 more sources

Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao, Jing Zhou, Jing Wang, Si‐Nan Zhao, Zhan‐Sheng Zhao, Qian Wang, Ya‐Nan Xie, Wei Jiao   +7 more
wiley   +1 more source

Functional orthogonality of parvoviral phospholipase A₂ domains in adeno-associated virus transduction. [PDF]

J Virol
Hull JA, Fusco RM, Tan J, Ochoa MA, Hall A, Wan X, Loeb E, Asokan A.   +7 more
europepmc   +1 more source