Results 241 to 250 of about 396,665 (375)

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors [PDF]

, 2020
al., et, Cooper, Jonathan D., Karda, Rajvinder   +2 more
core   +1 more source

Bibliography on inactivation of viruses and rickettsiae by heat [PDF]

Inactivation of viruses and rickettsiae by heat ...
Homann, L. M., Watson, M. S.
core   +1 more source

Adeno-associated virus-based gene therapy for hemophilia-addressing the gaps. [PDF]

Res Pract Thromb Haemost
Miesbach W, Batty P, Chowdary P, Fong S, Kaczmarek R, Leebeek FWG, Long B, Mahlangu J, Makris M, Pierce GF, Pipe SW, Srivastava A, Voorberg J, Peyvandi F.   +13 more
europepmc   +1 more source

Rescue and Autonomous Replication of Adeno-Associated Virus Type 2 Genomes Containing Rep-Binding Site Mutations in the Viral p5 Promoter [PDF]

, 1998
Xu-Shan Wang, Arun Srivastava
openalex   +1 more source

An adeno-associated virus vector.

Uirusu, 1987
openaire   +3 more sources

Techno‐Economic Analysis of Membrane‐Based Purification Platforms for AAV Vector Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Technologies for large‐scale manufacturing of viral vectors for gene therapies, such as tangential flow filtration and membrane chromatography, are under development. In these early stages of process development, techno‐economic analyses are useful for identifying membrane properties yielding the greatest impact on process performance. In this
Juan J. Romero, Eleanor W. Jenkins, Jacob I. Monroe, S. Ranil Wickramasinghe, Xianghong Qian, Dibakar Bhattacharyya, Scott M. Husson   +6 more
wiley   +1 more source

Overexpression of interleukin-4 using adeno-associated virus is a potential strategy to enhance bone regeneration. [PDF]

JBMR Plus
Kim H, Kim KH, Kang L, Seol YJ, Chung SH, Park SY.   +5 more
europepmc   +1 more source

Enrichment of Full AAV2 Using Multicolumn Countercurrent Solvent Gradient Purification (MCSGP)

Biotechnology and Bioengineering, EarlyView.
The multicolumn countercurrent solvent gradient purification (MCSGP) method was evaluated as a method to enhance the separation of empty and full capsids during AAV2 purification. The results demonstrated an enrichment of full AAV2 particles using MCSGP.
Julia M. Müller, Tereza Müllerová, Daniela Tobler, Damian Hauri, Richard Plieninger, Yuki Higuchi, Ryosuke Takahashi, Sebastian Vogg, Thomas Müller‐Späth, Thomas K. Villiger   +9 more
wiley   +1 more source

Real-time genome imaging of host interactions in adeno-associated virus genome release. [PDF]

iScience
Bustamante-Jaramillo LF, Yue L, Fingal J, Rydell G, Johansson M, Edreira T, Müller OJ, Hille S, Müller M, Gallardo F, Chen Q, Blondot ML, Kann M.   +12 more
europepmc   +1 more source