Results 261 to 270 of about 396,665 (375)

Transcriptomic functional characterization of recombinant adeno‐associated virus producing cell line adapted to suspension‐growth

Biotechnology Progress, EarlyView.
Abstract Recombinant adeno‐associated virus (rAAV) is a widely used delivery vehicle in gene therapy. A scalable production technology is essential for its wide clinical applications. We have taken a synthetic biology approach to generate HEK293‐based cell lines which harbor integrated genetic elements encoding essential AAV and adenoviral helper ...
Han‐Jung Kuo, Prahalad Srinivasan, Yu‐Chieh Lin, Min Lu, Carissa Rungkittikhun, Qi Zhang, Wei‐Shou Hu   +6 more
wiley   +1 more source

Adeno-associated virus expressing a blood-brain barrier-penetrating enzyme improves GM1 gangliosidosis in a preclinical model. [PDF]

J Clin Invest
Matsushima SK, Shimada Y, Kinoshita M, Nagashima T, Okamoto S, Iizuka S, Takagi H, Iizuka S, Higuchi T, Hioki H, Watabe AM, Sonoda H, Ohashi T, Kobayashi H.   +13 more
europepmc   +1 more source

Site-Specific Integration of Adeno-Associated Virus into an Episome with the Target Locus via a Deletion-Substitution Mechanism [PDF]

, 1998
Julie Dyall, Kenneth I. Berns
openalex   +1 more source

A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS‐CoV‐2 spike protein production as a vaccine antigen

Biotechnology Progress, EarlyView.
Abstract Fed‐batch recombinant therapeutic protein (RTP) production processes utilizing Chinese Hamster Ovary (CHO) cells can take a long period of time (>10 days). Within this period, not all critical features may be measured routinely, and in fact, some are only measured once the process is terminated, complicating decision making.
Sebastian‐Juan Reyes, Robert Voyer, Yves Durocher, Olivier Henry, Phuong Lan Pham   +4 more
wiley   +1 more source

Adeno-Associated Virus Vectors: Principles, Practices, and Prospects in Gene Therapy. [PDF]

Viruses
Zwi-Dantsis L, Mohamed S, Massaro G, Moeendarbary E.   +3 more
europepmc   +1 more source

Biochemical Characterization of Adeno-Associated Virus Rep68 DNA Helicase and ATPase Activities

, 1999
Xiaohuai Zhou, Irene Zolotukhin, Dong‐Soo Im, Nicholas Muzyczka   +3 more
openalex   +1 more source

An Alternate Route for Adeno-associated Virus (AAV) Entry Independent of AAV Receptor

Journal of Virology, 2018
Amanda M. Dudek, Sirika Pillay, A. Puschnik, C. Nagamine, Fang Cheng, J. Qiu, J. Carette, L. Vandenberghe   +7 more
semanticscholar   +1 more source

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, Accepted Article.
Upon cell stimulation, mammalian cells activate various signaling proteins and lipids by recruiting their upstream regulators to the inner leaflet of the plasma membrane (PM), which in turn determines their cellular response. Therefore, artificially inducing protein translocation to the PM is an effective strategy for dissecting cell signaling networks
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source

A comparison of SWATH-MS methods for measurement of residual host cell proteins in adeno-associated virus preparations. [PDF]

Front Bioeng Biotechnol
Leibiger TM, Min L, Lee KH.
europepmc   +1 more source

Adeno‐associated virus‐mediated gene delivery [PDF]

, 1999
Richard O. Snyder
openalex   +1 more source