Results 31 to 40 of about 426,766 (100)

A Prospective, Molecular Epidemiology Study of EGFR Mutations in Asian Patients with Advanced Non–Small-Cell Lung Cancer of Adenocarcinoma Histology (PIONEER)

open access: yesJournal of Thoracic Oncology, 2014
Introduction: PIONEER (NCT01185314) was a prospective, multinational, epidemiological study of epidermal growth factor receptor (EGFR) mutations in patients from Asia with newly diagnosed advanced lung adenocarcinoma. Methods: Eligible patients (aged ≥20
Yuankai Shi   +9 more
semanticscholar   +1 more source

Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial.

open access: yesJournal of Clinical Oncology, 2011
PURPOSE After curative resection, the prognosis of gastroesophageal adenocarcinoma is poor. This phase III trial was designed to evaluate the benefit in overall survival (OS) of perioperative fluorouracil plus cisplatin in resectable gastroesophageal ...
M. Ychou   +12 more
semanticscholar   +1 more source

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.

open access: yesCancer Discovery, 2015
UNLABELLED The molecular underpinnings that drive the heterogeneity of KRAS-mutant lung adenocarcinoma are poorly characterized. We performed an integrative analysis of genomic, transcriptomic, and proteomic data from early-stage and chemorefractory lung
F. Skoulidis   +36 more
semanticscholar   +1 more source

Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy

open access: yesNature Network Boston, 2011
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease. Overall survival is typically 6 months from diagnosis. Numerous phase 3 trials of agents effective in other malignancies have failed to benefit unselected PDA populations, although patients do ...
E. Collisson   +17 more
semanticscholar   +1 more source

A comparison of multimodal therapy and surgery for esophageal adenocarcinoma.

open access: yesNew England Journal of Medicine, 1996
BACKGROUND Uncontrolled studies suggest that a combination of chemotherapy and radiotherapy improves the survival of patients with esophageal adenocarcinoma. We conducted a prospective, randomized trial comparing surgery alone with combined chemotherapy,
T. Walsh   +5 more
semanticscholar   +1 more source

The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma.

open access: yesCancer Research, 2018
Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs.
M. Qiu   +14 more
semanticscholar   +1 more source

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

open access: yesJournal of the American Medical Association (JAMA), 2008
CONTEXT MicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer. No study has evaluated the association between microRNA expression patterns and colon cancer prognosis or therapeutic outcome.
Aaron J. Schetter   +13 more
semanticscholar   +1 more source

Genomic and immune profiling of pre-invasive lung adenocarcinoma

open access: yesNature Communications, 2019
Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood.
Haiquan Chen   +39 more
semanticscholar   +1 more source

Proteogenomic characterization of pancreatic ductal adenocarcinoma

open access: yesCell, 2021
L. Cao   +138 more
semanticscholar   +1 more source

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