Results 81 to 90 of about 987,160 (289)

Tumor-associated microbiome features of metastatic colorectal cancer and clinical implications

Frontiers in Oncology
BackgroundColon microbiome composition contributes to the pathogenesis of colorectal cancer (CRC) and prognosis. We analyzed 16S rRNA sequencing data from tumor samples of patients with metastatic CRC and determined the clinical implications.Materials ...
Ho Jung An, Ho Jung An, Mira A. Partha, HoJoon Lee, Billy T. Lau, Dmitri S. Pavlichin, Alison Almeda, Anna C. Hooker, Giwon Shin, Hanlee P. Ji, Hanlee P. Ji   +10 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

EGFR Mutation Detection in Whole Slide Images of Non‐Small Cell Lung Cancers Using a Two‐Stage Deep Transfer Learning Approach

Cancer Medicine
Background Lung cancer (LC) is the leading cause of cancer death worldwide. Non‐small cell lung cancer is the most frequent and includes adenocarcinoma and squamous cell carcinoma. Currently, LC treatment is based on tumor molecular profiling.
Michele Zanoletti, Filippo Ugolini, Laila El Bachiri, Valeria Pasini, Marco Laurino, Francesco De Logu, Eleonora Melissa, Carolina Marchi, Maria Colombino, Daniela Massi, Guido Rindi, Camilla Eva Comin, Giuseppe Palmieri, Antonio Cossu   +13 more
doaj   +1 more source

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis [PDF]

, 2014
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes.
Anderson, M, Bailey, P, Barbour, A, Bruxner, T, Campbell, P, Christ, A, Fink, J, Gotley, D, Grimmond, S, Harliwong, I, Hayward, N, Holmes, O, Hussey, D, Idrisoglu, S, Kazakoff, S, Krause, L, Lampe, G, Leonard, C, Loffler, K, Lord, R, Manning, S, Miller, D, Nancarrow, D, Newell, F, Nones, K, Nourbakhsh, E, Nourse, C, Patch, A, Pearson, J, Phillips, W, Quek, K, Quinn, M, Reid, L, Simpson, P, Smithers, B, Tang, Y, Waddell, N, Waddell, N, Watson, D, Wayte, N, Whiteman, D, Wilson, P, Wood, S, Xu, Q   +43 more
core   +4 more sources

Drug metabolism‐related eight‐gene signature can predict the prognosis of gastric adenocarcinoma [PDF]

, 2021
Hongmei Yin, Qiong He, Jia Chen, Zhen Li, Wanli Yang, Xiaobo Hu   +5 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Malignant Transformation in Tailgut Cyst Presenting as Retrorectal Adenosquamous Carcinoma: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Tailgut cysts are rare congenital retrorectal lesions that can rarely undergo malignant transformation. Occurring predominantly in middle-aged females, these lesions are mostly asymptomatic, with rare symptoms arising mostly in association with ...
Dipkana Das, Raya Banerjee, Durgaprasad Nanda, Namrata Maity   +3 more
doaj   +1 more source

Analysis of the Clinicopathologic Characteristics of Lung Adenocarcinoma With CTNNB1 Mutation

Frontiers in Genetics, 2020
IntroductionLung adenocarcinoma with CTNNB1 mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied.MethodsA total of 564 lung adenocarcinoma patients were enrolled in this ...
Chao Zhou, Chao Zhou, Wentao Li, Jinchen Shao, Jikai Zhao, Chang Chen   +5 more
doaj   +1 more source

AKT activation controls cell survival in response to HDAC6 inhibition. [PDF]

, 2016
HDAC6 is emerging as an important therapeutic target for cancer. We investigated mechanisms responsible for survival of tumor cells treated with a HDAC6 inhibitor.
Aboagye, EO, Ali, T, Kaliszczak, M, Trousil, S   +3 more
core   +1 more source

Tumor differentiation impacts response to neoadjuvant therapy and survival in patients with esophageal adenocarcinoma [PDF]

, 2023
Sarah C. McKay, Brian E. Louie, Daniela Molena, Weston Andrews, Thomas Boerner, Wayne L. Hofstetter, Jonathan Yeung, Gail Darling, Ahmed Sharata, Christian G. Peyré, Colin P. Dunn, John C. Lipham, Horia Marginean, Steven R. DeMeester   +13 more
openalex   +1 more source