Results 41 to 50 of about 96,959 (221)

Exploring the interdependencies of research funders in the UK [PDF]

, 2014
Investment in medical research is vital to the continuing improvement of the UK's health and wealth. It is through research that we expand our understanding of disease and develop new treatments for patients.
Crane, P, Farrell, C, Garau, M, Grassano, N, Hernandez-Villafuerte, K, Hopkins, M M, Hutton, J, Lang, F, Mawer, A, Pateman, C, Rotolo, D, Shah, K, Sharp, T, Sussex, J   +13 more
core   +1 more source

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
wiley   +1 more source

Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9 [PDF]

, 2013
Background The identification of new serum biomarkers with high sensitivity and specificity is an important priority in pancreatic cancer research.
Blasutig, Ivan M, Chan, Alison, Diamandis, Eleftherios P, Dimitromanolakis, Apostolos, Gallinger, Steven, Haun, Randy S, Makawita, Shalini, Soleas, Ireena, Soosaipillai, Antoninus   +8 more
core   +2 more sources

The pathophysiological consequences of somatostatin receptor internalization and resistance [PDF]

, 2003
Somatostatin receptors expressed on tumor cells form the rationale for somatostatin analog treatment of patients with somatostatin receptor-positive neuroendocrine tumors.
Hofland, L.J. (Leo), Lamberts, S.W.J. (Steven)   +1 more
core   +3 more sources

Clinical Significance of Skeletal Fat‐to‐Muscle Ratio in Idiopathic Hyperaldosteronism

Clinical Endocrinology, Volume 103, Issue 4, Page 429-435, October 2025.
ABSTRACT Objective The objective of this study is to evaluate the correlation between the fat‐to‐muscle ratio (FMR) and insulin resistance (IR) with aldosterone production among patients with idiopathic hyperaldosteronism (IHA). Methods Patients with primary aldosteronism were screened from those with secondary hypertension and then subtyped via ...
Yuhe Jiang, Dan Li, Cassie Chen Cao, Wenjing Feng, Ruidong Liu, Yinfei Xu, Caixia Cao   +6 more
wiley   +1 more source

Use of DNA Methylation Profiling as a Molecular Classification Tool for Paediatric Central Nervous System Tumours: A Middle‐Income Country Population–Based Study

Neuropathology and Applied Neurobiology, Volume 51, Issue 5, October 2025.
ABSTRACT Paediatric central nervous system (CNS) tumours are the second most common childhood malignancy and the leading cause of cancer‐related mortality in this age group. Histopathological diagnosis can be challenging, particularly for rare or ambiguous tumours, and may result in misclassification.
Mayara F. Euzébio, Felipe L. T. Silva, Iva L. Hoffmann, Juliana S. Ruas, Larissa Akemi Kido, Dieila G. de Lima, Luciano Queiroz, Izilda A. Cardinalli, Ana Luiza Seidinger, Suelen Nascimento, Helder Tedeschi, Renato D. Puga, Priscila Pini Zenatti Sales, Patricia Y. Jotta, Mariana Maschietto   +14 more
wiley   +1 more source

Somatostatin receptors in gastroentero-pancreatic neuroendocrine tumours [PDF]

, 2003
Five somatostatin receptor (sst) subtype genes, sst(1), sst(2), sst(3), sst(4) and sst(5), have been cloned and characterised. The five sst subtypes all bind natural somatostatin-14 and somatostatin-28 with high affinity.
Herder, W.W. (Wouter) de, Hofland, L.J. (Leo), Lamberts, S.W.J. (Steven), Lely, A-J. (Aart-Jan) van der   +3 more
core   +2 more sources

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, Volume 15, Issue 9, Page 1383-1405, September 2025.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin [PDF]

, 2014
Somatostatin (SST) is a regulatory peptide and acts as an endogenous inhibitory regulator of the secretory and proliferative responses of target cells. SST's actions are mediated by a family of seven transmembrane domain G protein-coupled receptors that ...
Abrol, Ravinder, Brunicardi, F. Charles, Liu, Shi-He, Nemunaitis, John, Pandol, Stephen J., Rozengurt, Enrique, Sanchez, Robbi, Sinnett-Smith, Jim, Wu, James, Yu, Juehua, Zhou, Guisheng   +10 more
core   +2 more sources

Molecular Mechanisms of Secreting Vesicle Biogenesis and Secretion in Chronic Degenerative Diseases [PDF]

, 2012
Regulated trafficking and secretion of insulin by the β cell of the endocrine pancreas is critical to maintain our body energy homeostasis. Disruption of these processes typically leads to hyperglycemia and the complications of diabetes.
Qiao, Xinxian
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