Results 1 to 10 of about 34,560 (181)
Adenomatous Polyposis Coli (APC) in cell migration [PDF]
European Journal of Cell Biology, 2022 Adenomatous Polyposis Coli (APC) protein is mostly known as a tumor suppressor that regulates Wnt signaling, but is also an important cytoskeletal protein.
Xingyuan Fang, Tatyana M. Svitkina
doaj +4 more sources
Familial polyposis coli: the management of desmoid tumor bleeding [PDF]
Open Medicine, 2019 There is currently no standard treatment for desmoid tumors (DTs) associated with familial polyposis coli (FAP). Familial adenomatous polyposis in DT patients is sometimes a life-threatening condition.
Calogero Armando +11 more
doaj +2 more sources
Familial adenomatous polyposis coli
Journal of the Belgian Society of Radiology, 2011 Background: A 53-year-old male patient with a familial history of colon carcinoma presented with stool changes and abdominal cramps. There was no weight loss nor signs of blood in the stool.
K Boeren, Y Vankan, D Perdieus
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Adenomatous polyposis coli in cancer and therapeutic implications [PDF]
Oncology Reviews, 2021 Inactivating mutations of the adenomatous polyposis coli (APC) gene and consequential upregulation of the Wnt signaling pathway are critical initiators in the development of colorectal cancer (CRC), the third most common cancer in the United States for ...
Olivia Noe +7 more
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Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22. [PDF]
PLoS Biol, 2019 Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains intestinal homeostasis and promotes wound healing and tissue regeneration, which can support the growth of colorectal tumours.
Chen Y +5 more
europepmc +4 more sources
Adenomatous Polyposis Coli Gene Mutations in 22 Chinese Pedigrees with Familial Adenomatous Polyposis. [PDF]
Med Sci Monit, 2019 BACKGROUND Familial adenomatous polyposis (FAP), which has a very high tendency of progression to colorectal cancer, is mainly caused by mutations of the adenomatous polyposis coli (APC) gene. This study systematically screened the APC mutations and observed the correlation of APC mutations with clinical manifestations of FAP.
Wang D +7 more
europepmc +4 more sources
The Turkish Journal of Gastroenterology, 2022 Background: Familial adenomatous polyposis (OMIM #175100) and MUTYH-associated polyposis (OMIM #608456) are rare cancerprone disorders characterized by hundreds of adenomatous polyps in the colon and rectum, which have a high probability of malignant ...
Esra Arslan Ateş +6 more
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A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis
Cancer Biology & Medicine, 2021 Objective: In some patients with adenomatous polyposis, an identifiable pathogenic variant of known associated genes cannot be found. Researchers have studied this for decades; however, few new genes have been identified.
Mengyuan Yang +6 more
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TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis [PDF]
, 2015 Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes.
Creytens, David +8 more
core +6 more sources
A Two Generation of Familial Adenomatous Polyposis
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020 Familial adenomatous polyposis (FAP) is a part of genetic polyposis syndrome which is caused by germline mutation in the adenomatous polyposis coli (APC) gene located in chromosome 5q21. The pathognomonic features is formation of hundreds to thousands of
Lily Chandrawati, I Dewa Nyoman Wibawa
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