Results 101 to 110 of about 34,616 (236)

Clinical outcomes of gastric polyps and neoplasms in patients with familial adenomatous polyposis

Endoscopy International Open, 2017
Background and study aims Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome caused by a germline mutation in the adenomatous polyposis coli (APC) gene, characterized by the presence of more than 100 adenomatous polyps in the ...
Keiko Nakamura, Satoru Nonaka, Takeshi Nakajima, Tatsuo Yachida, Seiichiro Abe, Taku Sakamoto, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Takahisa Matsuda, Shigeki Sekine, Yukihide Kanemitsu, Hitoshi Katai, Yutaka Saito, Seiichi Hirota   +14 more
doaj   +1 more source

Adenocarcinoma arising in adenomatous polyposis coli

Sakarya Medical Journal, 2014
Familyal adenomatöz polipozi koli (FAP) özellikle kolon epitelinde çok sayıda polip oluşumuyla karakterize genetik geçişli bir sendromdur. Tedavi edilmediği takdirde kanser gelişme riski giderek artmaktadır. Rektal kanama ve karın ağrısı gibi aşikar semptomlardan dolayı hastalar genellikle erken tanı almaktadır.
YILMAZ, Eyüp Murat, ÖZDEN, Ferhat
openaire   +3 more sources

Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours [PDF]

, 2017
The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are β-catenin-binding sites.
Behrens, Jürgen, Daum, Gabriele, Derungs, Adrian, Kohler, Eva Maria, Schneikert, Jean   +4 more
core  

Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3‐Induced T Cell Activation in Preclinical Models

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
In OKT3‐treated human PBMCs, Wnt signaling was downregulated, and co‐treatment with the Wnt activator CHIR99021 reduced T cell activation and apoptosis. In humanized mice, transcriptomic profiling revealed upregulation of genes associated with T cell activation, cytokine and ROS production, and apoptosis, with downregulation of canonical Wnt signaling.
Myeongjin Choi, Duhyeon Park, Da‐Hee Lee, Chang Hoon Choi, Minseong Jo, Seo Yule Jeong, Seung Yeon Lim, Daeui Park, Kyoung‐Sik Moon   +8 more
wiley   +1 more source

Familial adenomatous patients with desmoid tumours show increased expression of miR-34a in serum and high levels in tumours

, 2016
Familial adenomatous polyposis (FAP) is rare affecting 1 in 10,000 people and a subset (10%) are at risk of myofibroblastic desmoid tumours (DTs) after colectomy to prevent cancer. DTs are a major cause of morbidity and mortality.
Clark, SK, Feakins, R, Giannoulatou, E, Jeffery, R, Lewis, A, Lindsay, JO, Silver, A, Thompson, H, Walton, SJ, Yau, C   +9 more
core   +1 more source

Evaluation and Management of Thyroid Nodules: A Joint Consensus Statement From the British Thyroid Association (BTA), British Association of Endocrine and Thyroid Surgeons (BAETS) and Collaborating Bodies

Clinical Endocrinology, EarlyView.
Ram Moorthy, Saba P. Balasubramanian, Kate Farnell, Mairead Kelly, Gitta Madani, Mufaddal Moonim, Carla Moran, Julia Priestley, Michael Stechman, Emma Watts, Kristien Boelaert   +10 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, Volume 16, Issue 3, Page 532-541, March 2026.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Endogenous Repair in Vanishing White Matter

Annals of Neurology, Volume 99, Issue 3, Page 737-747, March 2026.
[Color figure can be viewed at www.annalsofneurology.org] Objective Vanishing white matter is a leukodystrophy with remarkable regional variation in disease severity. The cerebral and cerebellar white matter chronically degenerates, while stress‐induced episodes of rapid neurological deterioration coincide with the appearance of acute focal lesions in ...
Bonnie C. Plug, Jodie H.K. Man, Marjolein Breur, Erik Nutma, Menno D. Stellingwerff, Truus E.M. Abbink, Marianna Bugiani, Marjo S. van der Knaap   +7 more
wiley   +1 more source

Recurrent Fistula between Ileal Pouch and Vagina—Successful Treatment with a Gracilis Muscle Flap

Case Reports in Medicine, 2009
Fistulae between an ileal pouch and the vagina are an uncommon complication of ileal pouch-anal anastomosis following proctocolectomy and mucosectomy in patients with familial adenomatous polyposis coli.
Feride Aydin, Claus Ferdinand Eisenberger, Andreas Raffel, Alexander Rehders, Stefan Benedikt Hosch, Wolfram Trudo Knoefel   +5 more
doaj   +1 more source

IMMEDIATE AND LATE RESULTS OF ILEOSTOMY CLOSURE IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS UNDERGOING RESTORATIVE PROCTOCOLECTOMY BY OPEN OR LAPAROSCOPIC APPROACHES [PDF]

Arquivos de Gastroenterologia
Background: Restorative proctocolectomy (RPC) is a common surgical indication to manage familial adenomatous polyposis (FAP) patients. Objective: We compared outcomes after ileostomy closure in patients undergoing laparoscopic (LAP) or conventional ...
Fábio Guilherme CAMPOS, Carlos Augusto Real MARTINEZ, Carlos Frederico Sparapan MARQUES, Ulysses RIBEIRO JUNIOR, Paulo HERMAN   +4 more
doaj   +1 more source