Results 131 to 140 of about 20,064 (176)

Involvement of adenomatous polyposis coli in colorectal tumorigenesis

Frontiers in Bioscience - Landmark, 2005
Colorectal cancer arises after a series of mutations in various tumor suppressor and proto-oncogenes, each of which is accompanied by specific alterations and pathological conditions. Recent advances have contributed a great deal of understanding of the molecular basis of events that lead to colorectal tumorigenesis.
Aruna S Jaiswal
exaly   +3 more sources

Adenomatous polyposis coli and translational medicine

The Lancet, 1996
See page 433 Advances in molecular biological techniques in recent years have greatly increased our level of understanding about the mechanisms underlying carcinogenesis. Such advances have also enabled identification of genetic mutations associated with specific cancers.
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Adenomatous Polyposis Coli Gene Polyposis-Related Syndromes

American Journal of Gastroenterology
Gastrointestinal cancers, particularly those of the stomach and colorectum, are among the leading causes of cancer-related morbidity and mortality in the United States and worldwide. The adenomatous polyposis coli ( APC ) gene functions as a ...
Jennifer K. Maratt, Anneleise Frie, Jennifer M. Weiss   +2 more
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Adenomatous polyposis coli gene large deletions in Iranian patients with familial adenomatous polyposis

Indian Journal of Cancer, 2014
Context: Familial adenomatous polyposis (FAP) is one type of hereditary colon cancer with a large number of precancerous polyps that initiation to growth in childhood and adolescent. Mutation in adenomatous polyposis coli (APC) gene is the cause of FAP.
R, Kishani Farahani, M, Montazer Haghighi, H, Asadzadeh Aghdaei, F, Keshavarzi, M Y, Taleghani, F, Goodarzi, E, Nazemalhosseini-Mojarad, M R, Zali   +7 more
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Dental anomalies in familial adenomatous polyposis coli

Acta Odontologica Scandinavica, 1987
Forty-seven Danish and 50 Finnish patients with familial adenomatous polyposis coli (FPC) were studied by panoramic tomography (PTG) of the mandible, which showed dental abnormalities in 17% of the cases. Eleven patients (11%) had supernumerary teeth and/or compound osteomas, and nine patients (9%) had impacted permanent teeth.
J O, Søndergaard, S, Bülow, H, Järvinen, J, Wolf, I N, Witt, G, Tetens   +5 more
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Mutations of theAPC adenomatous polyposis coli) gene

Human Mutation, 1993
Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene plays a significant role in FAP and in sporadic tumors ...
H, Nagase, Y, Nakamura
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Unusual adenomatous polyps in juvenile polyposis coli

The American Journal of Surgical Pathology, 1982
A 14-year-old boy had an ileocolectomy for juvenile polyposis coli. Twenty-five years later he developed peculiar adenomatous polyps in his rectum. The polyps had irregularly shaped glands lined by cells with stratified, atypical nuclei. Some glands were distended with mucus, but otherwise the polyps did not resemble juvenile polyps. Two other types of
S E, Mills, R E, Fechner
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Familial Adenomatous Polyposis Coli

James S Wu, Wiland Homer O, Power Carolyn L   +2 more
exaly   +2 more sources

Biology of the Adenomatous Polyposis Coli Tumor Suppressor

Journal of Clinical Oncology, 2000
ABSTRACT: The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an inherited syndrome of colon cancer predisposition known as familial adenomatous polyposis coli (FAP). Mutation of APC is also found in 80% of all colorectal adenomas and carcinomas and is one of the earliest mutations in colon cancer progression. Similar
K H, Goss, J, Groden
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Adenomatous polyposis coli proteins and cell adhesion

Current Opinion in Cell Biology, 2004
Adenomatous polyposis coli (APC) is an important tumour suppressor in the mammalian intestinal epithelium. It binds to beta-catenin and its role as a tumour suppressor depends predominantly on its ability to downregulate soluble beta-catenin, a key effector of the Wnt signalling pathway.
Mariann, Bienz, Fumihiko, Hamada
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