Results 171 to 180 of about 22,051 (209)
Some of the next articles are maybe not open access.
Dental anomalies in familial adenomatous polyposis coli
Acta Odontologica Scandinavica, 1987Forty-seven Danish and 50 Finnish patients with familial adenomatous polyposis coli (FPC) were studied by panoramic tomography (PTG) of the mandible, which showed dental abnormalities in 17% of the cases. Eleven patients (11%) had supernumerary teeth and/or compound osteomas, and nine patients (9%) had impacted permanent teeth.
J O, Søndergaard +5 more
openaire +2 more sources
Mutations of theAPC adenomatous polyposis coli) gene
Human Mutation, 1993Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene plays a significant role in FAP and in sporadic tumors ...
H, Nagase, Y, Nakamura
openaire +2 more sources
Adenomatous Polyposis Coli Gene Polyposis-Related Syndromes
American Journal of GastroenterologyGastrointestinal cancers, particularly those of the stomach and colorectum, are among the leading causes of cancer-related morbidity and mortality in the United States and worldwide. The adenomatous polyposis coli ( APC ) gene functions as a tumor suppressor gene whose loss of function plays ...
Jennifer K. Maratt +2 more
openaire +2 more sources
Involvement of adenomatous polyposis coli in colorectal tumorigenesis
Frontiers in Bioscience, 2005Colorectal cancer arises after a series of mutations in various tumor suppressor and proto-oncogenes, each of which is accompanied by specific alterations and pathological conditions. Recent advances have contributed a great deal of understanding of the molecular basis of events that lead to colorectal tumorigenesis.
Aruna S, Jaiswal +2 more
openaire +2 more sources
The adenomatous polyposis coli gene and human cancers
Journal of Cancer Research and Clinical Oncology, 1995The APC (adenomatous polyposis coli) gene was isolated as a gene responsible for familial polyposis coli, an autosomal-dominant disease, characterized by development of hundreds to thousands of adenomatous polyps in the colon and rectum. However, recent studies revealed that inactivation of the APC gene also plays a significant role in development of ...
Yusuke Nakamura
exaly +3 more sources
Unusual adenomatous polyps in juvenile polyposis coli
The American Journal of Surgical Pathology, 1982A 14-year-old boy had an ileocolectomy for juvenile polyposis coli. Twenty-five years later he developed peculiar adenomatous polyps in his rectum. The polyps had irregularly shaped glands lined by cells with stratified, atypical nuclei. Some glands were distended with mucus, but otherwise the polyps did not resemble juvenile polyps. Two other types of
S E, Mills, R E, Fechner
openaire +2 more sources
Presymptomatic diagnosis of familial adenomatous polyposis coli
Diseases of the Colon & Rectum, 1994Familial adenomatous polyposis (FAP), an autosomal dominant inherited disease, confers a high risk of colon cancer, and recently the gene responsible for FAP, termed adenomatous polyposis coli (APC) gene, was identified and fully characterized.For the presymptomatic diagnosis of FAP, we have performed linkage studies using two polymorphic systems close
J G, Park +3 more
openaire +2 more sources
The adenomatous polyposis coli (APC) tumor suppressor
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1997Defects in the APC gene are inarguably linked to the progression of colon cancers that arise both sporadically and through the transmission of germline mutations. Genetic evidence from humans and mouse models suggest that APC is a classic tumor suppressor in that both alleles likely require inactivation for tumor growth to ensue.
openaire +2 more sources