Results 181 to 190 of about 34,811 (221)

Mutations of theAPC adenomatous polyposis coli) gene

Human Mutation, 1993
Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene plays a significant role in FAP and in sporadic tumors ...
H, Nagase, Y, Nakamura
openaire   +2 more sources

Presymptomatic direct detection of adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis

Human Genetics, 1993
The recent identification of the familial adenomatous polyposis (FAP) gene (designated as APC) enables conclusive genetic testing of at-risk family members for the specific mutation in families in which the germline gene mutation has been characterized.
G M, Petersen, C, Francomano, K, Kinzler, Y, Nakamura   +3 more
openaire   +2 more sources

The adenomatous polyposis coli (APC) tumor suppressor

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1997
Defects in the APC gene are inarguably linked to the progression of colon cancers that arise both sporadically and through the transmission of germline mutations. Genetic evidence from humans and mouse models suggest that APC is a classic tumor suppressor in that both alleles likely require inactivation for tumor growth to ensue.
openaire   +2 more sources

Intracranial Desmoid Tumor with Familial Adenomatous Polyposis Coli

Pediatric Neurosurgery, 2008
Intracranial desmoid tumors are extremely rare. The association of desmoid tumors with familial adenomatous polyposis coli was reported previously, with the tumors involving trunk and extremities. We report a 3.5-year-old girl with intracranial desmoid tumor with familial adenomatous polyposis coli. This condition in a child is rarely reported.
Nalan, Yazici, Bilgehan, Yalçin, Figen, Soylemezoğlu, Ayşenur, Cila, Nejat, Akalan, Yavuz, Koksal, Munevver, Buyukpamukçu   +6 more
openaire   +2 more sources

The adenomatous polyposis coli gene and human cancers

Journal of Cancer Research and Clinical Oncology, 1995
The APC (adenomatous polyposis coli) gene was isolated as a gene responsible for familial polyposis coli, an autosomal-dominant disease, characterized by development of hundreds to thousands of adenomatous polyps in the colon and rectum. However, recent studies revealed that inactivation of the APC gene also plays a significant role in development of ...
openaire   +2 more sources

Adenomatous Polyposis Coli

2016
Jonathan Alexander, Antonella Pirone, Michele Jacob   +2 more
openaire   +2 more sources

Adenomatous Polyposis Coli ☆

2013
I.M. Frayling, M.J. Arends
openaire   +1 more source

[Familial adenomatous polyposis coli--case report].

Orvosi hetilap, 2004
The authors report the case of a young 35 year-old male patient, investigated due to thrombocytosis for three years. First the diagnosis of chronic myeloproliferative disease was made. The diagnosis of familial adenomatous polyposis was only evident in advanced stage of the disease.
Péter László, Lakatos, Judit, Halász, Katalin, Keresztes, Péter, Fuszek, Márta, Jäckel, Anna, Poros, Krisztina, Morvay, László, Lakatos   +7 more
openaire   +1 more source

Adenomatous polyposis coli gene mutations in Irish pedigrees with familial adenomatous polyposis

Biochemical Society Transactions, 1995
M J, O'Sullivan, T, Mulcahy, C B, Suilleabhain, W O, Kirwan, C T, Doyle, T V, McCarthy   +5 more
openaire   +2 more sources

Hepatoblastoma and polyposis coli (familial adenomatous polyposis)

Medical and Pediatric Oncology, 1989
M, Phillips, C, Dicks-Mireaux, J, Kingston, M, Malone, C, Mitchell, J, Pritchard, E, Shafford, L, Spitz   +7 more
openaire   +2 more sources