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Adenomatous polyposis coli proteins and cell adhesion
Current Opinion in Cell Biology, 2004Adenomatous polyposis coli (APC) is an important tumour suppressor in the mammalian intestinal epithelium. It binds to beta-catenin and its role as a tumour suppressor depends predominantly on its ability to downregulate soluble beta-catenin, a key effector of the Wnt signalling pathway.
Mariann, Bienz, Fumihiko, Hamada
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Unusual adenomatous polyps in juvenile polyposis coli
The American Journal of Surgical Pathology, 1982A 14-year-old boy had an ileocolectomy for juvenile polyposis coli. Twenty-five years later he developed peculiar adenomatous polyps in his rectum. The polyps had irregularly shaped glands lined by cells with stratified, atypical nuclei. Some glands were distended with mucus, but otherwise the polyps did not resemble juvenile polyps. Two other types of
S E, Mills, R E, Fechner
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Adenomatous polyposis coli and translational medicine
The Lancet, 1996See page 433 Advances in molecular biological techniques in recent years have greatly increased our level of understanding about the mechanisms underlying carcinogenesis. Such advances have also enabled identification of genetic mutations associated with specific cancers.
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Indian Journal of Cancer, 2014
Context: Familial adenomatous polyposis (FAP) is one type of hereditary colon cancer with a large number of precancerous polyps that initiation to growth in childhood and adolescent. Mutation in adenomatous polyposis coli (APC) gene is the cause of FAP.
R, Kishani Farahani +7 more
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Context: Familial adenomatous polyposis (FAP) is one type of hereditary colon cancer with a large number of precancerous polyps that initiation to growth in childhood and adolescent. Mutation in adenomatous polyposis coli (APC) gene is the cause of FAP.
R, Kishani Farahani +7 more
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Mutations of theAPC adenomatous polyposis coli) gene
Human Mutation, 1993Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene plays a significant role in FAP and in sporadic tumors ...
H, Nagase, Y, Nakamura
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Human Genetics, 1993
The recent identification of the familial adenomatous polyposis (FAP) gene (designated as APC) enables conclusive genetic testing of at-risk family members for the specific mutation in families in which the germline gene mutation has been characterized.
G M, Petersen +3 more
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The recent identification of the familial adenomatous polyposis (FAP) gene (designated as APC) enables conclusive genetic testing of at-risk family members for the specific mutation in families in which the germline gene mutation has been characterized.
G M, Petersen +3 more
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The adenomatous polyposis coli (APC) tumor suppressor
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1997Defects in the APC gene are inarguably linked to the progression of colon cancers that arise both sporadically and through the transmission of germline mutations. Genetic evidence from humans and mouse models suggest that APC is a classic tumor suppressor in that both alleles likely require inactivation for tumor growth to ensue.
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Intracranial Desmoid Tumor with Familial Adenomatous Polyposis Coli
Pediatric Neurosurgery, 2008Intracranial desmoid tumors are extremely rare. The association of desmoid tumors with familial adenomatous polyposis coli was reported previously, with the tumors involving trunk and extremities. We report a 3.5-year-old girl with intracranial desmoid tumor with familial adenomatous polyposis coli. This condition in a child is rarely reported.
Nalan, Yazici +6 more
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The adenomatous polyposis coli gene and human cancers
Journal of Cancer Research and Clinical Oncology, 1995The APC (adenomatous polyposis coli) gene was isolated as a gene responsible for familial polyposis coli, an autosomal-dominant disease, characterized by development of hundreds to thousands of adenomatous polyps in the colon and rectum. However, recent studies revealed that inactivation of the APC gene also plays a significant role in development of ...
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