Results 61 to 70 of about 34,811 (221)

The adenomatous polyposis coli protein. [PDF]

Molecular Pathology, 1999
Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell.
openaire   +2 more sources

The adenomatous polyposis coli protein 30 years on

Seminars in Cell & Developmental Biology, 2023
Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space.
Abbott, James, Nathke, Inke S.
openaire   +3 more sources

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, EarlyView.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

Detection of a heterozygous germline APC mutation in a three-generation family with familial adenomatous polyposis using targeted massive parallel sequencing in Vietnam

BMC Medical Genetics, 2018
Background Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary syndrome characterised by the development of hundreds to thousands of adenomatous colonic polyps during the second decade of life. FAP is caused by germ line mutations in
Hoa Giang, Vu T Nguyen, Sinh D Nguyen, Huu-Phuc Nguyen, Binh T Vo, Truc M Nguyen, Nguyen H Nguyen, Kiet D Truong, Thanh-Thuy T Do, Minh-Duy Phan, Hoai-Nghia Nguyen   +10 more
doaj   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium [PDF]

, 2016
Aberrant Wnt signaling within breast cancer is associated with poor prognosis, but regulation of this pathway in breast tissue remains poorly understood and the consequences of immediate or long-term dysregulation remain elusive.
A Grigoriadis, A Imbert, A R Clarke, A Tanaka, AC Lesko, AI Khramtsov, AK Rajasekaran, AM Hassanein, AM Thompson, AR Moser, B Mann, BM Gumbiner, C Curtis, C S Daly, Cancer Genome Atlas N, CR Jarrett, CV Dang, D Sarrió, DJ Liao, DM Roberts, E López-Knowles, FC Geyer, G T Williams, H Clevers, H Clevers, H Clevers, I Van der Auwera, J H Van Es, J Quist, J Schneikert, J Watkins, JH van Es, JI Herschkowitz, JI Yook, JN Hutchinson, JS Michaelson, K Aoki, K Bray, K Furuuchi, K R Reed, K Umeda, K Wang, KY Ho, L D Ordonez, M Dolled-Filhart, M Jönsson, M Kashiwaba, M Reichert, M van der Meer, MM Suzuki, OJ Sansom, P Shaw, PW Schlosshauer, RA Neese, RC Gallagher, RS Chapman, S Irshad, S Khalil, S Mohinta, S Nelson, S Selbert, SB Sobottka, SJ Zardawi, SY Lin, TA Chan, TA DiMeo, TC He, TL Yang, TM Williams, Y Ahmed, Y Ando-Akatsuka, Z Jin, ZJ Wang   +72 more
core   +1 more source

Adenomatous polyposis coli gene as a gatekeeper.

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 2002
The Adenomatous Polyposis Coli (APC) Gene is a tumor suppressor gene located in the chromosome 5q21. It has a sequence of 2843 amino acids and a weight of 312 kD. The mutation of the APC gene occurs at the early stages of most sporadic colorectal cancers; and up to 30% in familial adenomatous polyposis.
Nakayama, Takamori, Morishita, Tetsuo, Kamiya, Toshiaki   +2 more
openaire   +4 more sources

Characterization of postnatal brain injury and behavioural deficits in a rat model of placental insufficiency‐induced fetal growth restriction

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal growth restriction (FGR) is a common pregnancy complication associated with long‐term neurodevelopmental impairments. Using the reduced uterine perfusion pressure (RUPP) rat model of placental insufficiency‐induced FGR, this study demonstrates that FGR leads to persistent anatomical, histological and behavioural ...
Judit Alhama‐Riba, Caroline G. M. de Theije, Valentina Salvi, Dominique Viveen, Sebastiaan W. T. Corstjens, Marijke. E. J. Achterberg, Yohan van de Looij, Freek E. Hoebeek, Cora H. A. Nijboer   +8 more
wiley   +1 more source

Role of APC and DNA mismatch repair genes in the development of colorectal cancers

Molecular Cancer, 2003
Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S ...
Roy Deodutta, Narayan Satya
doaj   +1 more source

Availability Of Dental Anomaly Phenotype In Individuals With Familial Adenomatous Polyposis [PDF]

, 2014
Background: Mutations in the APC gene cause familial adenomatous polyposis (FAP), an autosomal dominant colorectal cancer predisposition associated with the development of hundreds to thousands of adenomatous colorectal polyps beginning in childhood or ...
Lewis, Andrea M
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