Results 61 to 70 of about 22,051 (209)

APC Promoter Methylation in Gastrointestinal Cancer

Frontiers in Oncology, 2021
The adenomatous polyposis coli (APC) gene, known as tumor suppressor gene, has the two promoters 1A and 1B. Researches on APC have usually focused on its loss-of-function variants causing familial adenomatous polyposis.
Lila Zhu, Xinyu Li, Ying Yuan, Ying Yuan, Caixia Dong, Mengyuan Yang, Mengyuan Yang   +6 more
doaj   +1 more source

Characterization of postnatal brain injury and behavioural deficits in a rat model of placental insufficiency‐induced fetal growth restriction

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal growth restriction (FGR) is a common pregnancy complication associated with long‐term neurodevelopmental impairments. Using the reduced uterine perfusion pressure (RUPP) rat model of placental insufficiency‐induced FGR, this study demonstrates that FGR leads to persistent anatomical, histological and behavioural ...
Judit Alhama‐Riba, Caroline G. M. de Theije, Valentina Salvi, Dominique Viveen, Sebastiaan W. T. Corstjens, Marijke. E. J. Achterberg, Yohan van de Looij, Freek E. Hoebeek, Cora H. A. Nijboer   +8 more
wiley   +1 more source

Attenuated adenomatous polyposis coli - The role of ascertainment bias through failure to dye-spray at colonoscopy

, 1999
PURPOSE: The aim of this study is to show that the diagnosis of attenuated adenomatous polyposis coli must be made with caution and certainly only after adequate colonic examination with dye-spray.
Clark, Susan, Neale, Kay, Phillips, Robin K. S., Wallace, Marina, Frayling, Ian   +4 more
core   +1 more source

Detection of a heterozygous germline APC mutation in a three-generation family with familial adenomatous polyposis using targeted massive parallel sequencing in Vietnam

BMC Medical Genetics, 2018
Background Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary syndrome characterised by the development of hundreds to thousands of adenomatous colonic polyps during the second decade of life. FAP is caused by germ line mutations in
Hoa Giang, Vu T Nguyen, Sinh D Nguyen, Huu-Phuc Nguyen, Binh T Vo, Truc M Nguyen, Nguyen H Nguyen, Kiet D Truong, Thanh-Thuy T Do, Minh-Duy Phan, Hoai-Nghia Nguyen   +10 more
doaj   +1 more source

Integration of Three‐Dimensional Cell Culture Techniques and Photobiomodulation for Supportive Differentiation of Adipose‐Derived Stem Cells into Smooth Muscle

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Photobiomodulation (PBM) has gained recognition as a promising, non‐invasive strategy to enhance the differentiation of adipose‐derived stem cells (ADSCs) into smooth muscle cells (SMCs), particularly when used together with a three‐dimensional (3D) hydrogel culture system.
Christevie Mbuyu, Heidi Abrahamse, Anine Crous   +2 more
wiley   +1 more source

Spontaneous Immortalization of Clinically Normal Colon-Derived Fibroblasts from a Familial Adenomatous Polyposis Patient

Neoplasia: An International Journal for Oncology Research, 2004
Normal human diploid cells do not spontaneously immortalize in culture, but instead enter replicative senescence after a finite number of population doublings.
Nicholas R. Forsyth, Carmela P. Morales, Shirish Damle, Bruce Boman, Woodring E. Wright, Levy Kopelovich, Jerry W. Shay   +6 more
doaj   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

Adenomatous Polyposis Coli Regulates Oligodendroglial Development [PDF]

The Journal of Neuroscience, 2013
The expression of the gut tumor suppressor gene adenomatous polyposis coli (Apc) and its role in the oligodendroglial lineage are poorly understood. We found that immunoreactive APC is transiently induced in the oligodendroglial lineage during both normal myelination and remyelination following toxin-induced, genetic, or autoimmune demyelination murine
Jordan, Lang, Yoshiko, Maeda, Peter, Bannerman, Jie, Xu, Makoto, Horiuchi, David, Pleasure, Fuzheng, Guo   +6 more
openaire   +2 more sources

Intracranial desmoid tumor with familial adenomatous polyposis coli

, 2008
Intracranial desmoid tumors are extremely rare. The association of desmoid tumors with familial adenomatous polyposis coli was reported previously, with the tumors involving trunk and extremities.
Cila, Aysenur, Koesal, Yavuz, AKALAN, NEJAT, YAZICI, NALAN, Soeylemezoglu, Figen, Bueyuekpamukcu, Muenevver, YALÇIN, BİLGEHAN   +6 more
core   +1 more source

A Novel Germline Mutation of the APC Gene: A Case Report of Familial Adenomatous Polyposis Requiring Repeated Endoscopic Resections for Gastroduodenal Polyps

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2016
Familial adenomatous polyposis (FAP) is a precancerous clinical entity, which is characterized by the development of numerous adenomatous polyps throughout the colon and rectum.
Jun Hui Lee, Joon Weon Jang, Byung-Wook Kim, Eun Su Park, Sang Yong Kim   +4 more
doaj   +1 more source