Results 101 to 110 of about 712,877 (361)

Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer [PDF]

Journal of Cellular Physiology, 2017
Tumor cells overcome anti‐tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and immune cells in tumor microenvironment to suppress anti‐tumor responses.
Mohammad H. Kazemi, Sahar Raoofi Mohseni, Mohammad Hojjat‐Farsangi, Enayat Anvari, Ghasem Ghalamfarsa, Hamed Mohammadi, Farhad Jadidi‐Niaragh   +6 more
openaire   +4 more sources

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

HO-1 and CD39: It Takes Two to Protect the Realm

Frontiers in Immunology, 2019
Cellular protective mechanisms exist to ensure survival of the cells and are a fundamental feature of all cells that is necessary for adapting to changes in the environment.
Ghee Rye Lee, Shahzad Shaefi, Leo E. Otterbein   +2 more
doaj   +1 more source

Influence of contrast media dose and osmolality on the diagnostic performance of contrast fractional flow reserve [PDF]

, 2017
Background—Contrast fractional flow reserve (cFFR) is a method for assessing functional significance of coronary stenoses, which is more accurate than resting indices and does not require adenosine.
Berry, Colin, Choi, Dong-Hyun, De Bruyne, Bernard, Fearon, William F., Gould, K. Lance, Jeremias, Allen, Johnson, Nils P., Kobayashi, Yuhei, Nishi, Takeshi, Oldroyd, Keith G., Pijls, Nico H.J.   +10 more
core   +1 more source

Dual‐Nanoparticle Engineered Hydrogel Reverses Bicellular Oxidative Stress to Accelerate Diabetic Fracture Healing

Advanced Functional Materials, EarlyView.
CD105‐LNPs and PS‐LNPs can deliver α‐lipoic acid to bone marrow mesenchymal stem cells and bone marrow‐derived macrophages, reversing high glucose‐induced oxidative stress while enhancing osteogenesis and M2 polarization. Integrating both nanoparticles into glucose‐responsive hyaluronic acid hydrogel forms DLNPs@HA hydrogel, which accelerates diabetic ...
Yanzhi Zhao, Weixian Hu, Shengming Zhang, Yuheng Liao, Kangkang Zha, Chenyan Yu, Zhenhe Zhang, Wenqian Zhang, Bobin Mi, Faqi Cao, Guohui Liu, Wu Zhou   +11 more
wiley   +1 more source

Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury [PDF]

, 2005
Acute respiratory distress syndrome (ARDS) usually requires symptomatic supportive therapy by intubation and mechanical ventilation with the supplemental use of high oxygen concentrations.
, Agorreta, Ahmad, Akio Ohta, Alexander Chouker, Andonegui, Apasov, Bell, Bosco, Brown, Carvalho, Charles Caldwell, Chen, Chris Haslett, Decking, Derevianko, Dharmana, Dmitry Lukashev, Edward Jackson, Eltzschig, Estenssoro, Freeman, Gardinali, Goss, Guida, Hasko, Headley, Iris Bittmann, Ishida, Khoa, Kotani, Lachmann, Lahat, LeClaire, Leeper-Woodford, Linden, Lukashev, Madjdpour, Malbouisson, Manfred Thiel, Martin, Matuschak, Michail V Sitkovsky, Nader-Djalal, Ndengele, Ohta, Patrick Smith, Pietersma, Pinhu, Pizov, Regel, Simms, Sitkovsky, Sue, Sullivan, Tateda, Thiel, Thiel, Tremblay, Tsan, Uchiba, Ward, Wieland   +62 more
core   +5 more sources

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Interindividual Variations in the Adenosine‐Induced Hemodynamics During Fractional Flow Reserve Evaluation: Implications for the Use of Quantitative Flow Ratio in Assessing Intermediate Coronary Stenoses

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Quantitative flow ratio (QFR), a novel functional angiography technique, computes fractional flow reserve (FFR) without pressure wires or adenosine.
Hernán Mejía‐Rentería, Francesco María Lauri, Joo Myung Lee, Angela McInerney, Nina W. van der Hoeven, Guus A. de Waard, Antonio Fernández‐Ortiz, Carlos Macaya, Paul Knaapen, Niels van Royen, Bon‐Kwon Koo, Javier Escaned   +11 more
doaj   +1 more source

An open-label, one-arm, dose-escalation study to evaluate safety and tolerability of extremely low frequency magnetic fields in acute ischemic stroke [PDF]

, 2017
Extremely low frequency magnetic fields (ELF-MF) could be an alternative neuroprotective approach for ischemic stroke because preclinical studies have demonstrated their effects on the mechanisms underlying ischemic damage. The purpose of this open-label,
Apollonio, Francesca, Cadossi, Ruggero, Camera, Francesca, Capone, Fioravante, Di Lazzaro, Vincenzo, Liberti, Micaela, Quattrocchi Carlo, Cosimo, Setti, Stefania   +7 more
core   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source